The phosphoinositide 3-kinase pathway and therapy resistance in cancer

F1000prime Reports
Kristin K Brown, Alex Toker

Abstract

The phosphoinositide 3-kinase (PI3K)/Akt/mechanistic target of rapamycin (mTOR) signaling network is a master regulator of processes that contribute to tumorigenesis and tumor maintenance. The PI3K pathway also plays a critical role in driving resistance to diverse anti-cancer therapies. This review article focuses on mechanisms by which the PI3K pathway contributes to therapy resistance in cancer, and highlights potential combination therapy strategies to circumvent resistance driven by PI3K signaling. In addition, resistance mechanisms that limit the clinical efficacy of small molecule inhibitors of the PI3K pathway are discussed.

Citations

Jul 15, 2015·Expert Review of Molecular Diagnostics·Chun Man LiSze Chuen Cesar Wong
Sep 26, 2015·Biomolecules·Valentina Iadevaia, André P Gerber
Aug 16, 2015·Cancer Treatment Reviews·Valentina D'AmatoRoberto Bianco
Sep 24, 2016·Leukemia & Lymphoma·Akhilendra Kumar Maurya, Manjula Vinayak
Apr 13, 2017·Expert Opinion on Drug Discovery·Robert Musiol
Mar 10, 2017·Cancers·David GyoriLen R Stephens
Jan 11, 2017·Medicine·Dongchan Ryu, Chaeyoung Lee
Jul 1, 2017·PloS One·Ping ZhaoGiselle Saulnier Sholler
Jan 17, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Giuseppe Curigliano, Rashmi R Shah
Oct 9, 2019·Journal of Biochemical and Molecular Toxicology·Nirmala SubramaniamDevaki Thiruvengadam
Feb 13, 2020·Biochemical Society Transactions·William G KerrJohn D Chisholm
Oct 28, 2019·Mini Reviews in Medicinal Chemistry·Yutao XieYajun Cao
Feb 14, 2020·Anti-cancer Agents in Medicinal Chemistry·Isadora C SilveiraVirgínia O Crema
Apr 18, 2018·Frontiers in Immunology·Xinglong QuShucheng Hua
Nov 30, 2016·World Journal of Gastroenterology : WJG·Zhao-Shan NiuWen-Hong Wang
Apr 15, 2020·International Journal of Molecular Sciences·Silvia ZappavignaMichele Caraglia
Sep 26, 2020·Cell Death & Disease·Rui LiuYuanyan Liu
Feb 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lili GuoChangyu Wang
Sep 17, 2020·Cells·Sarah A JeffreysTherese M Becker
Mar 1, 2020·Nature Communications·Vaishali Jayashankar, Aimee L Edinger
Feb 11, 2020·Frontiers in Cell and Developmental Biology·Diego PerettiSima Lev
Mar 15, 2018·Science Signaling·Emilie ClementAlex Toker
Sep 24, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Annamaria MartoranaAntonino Lauria
Jun 15, 2016·Molecular Cancer Therapeutics·Casey StottrupY Rebecca Chin

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Methods Mentioned

BETA
xenografts
xenograft

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