The Photobiology of Lutein and Zeaxanthin in the Eye

Journal of Ophthalmology
Joan E Roberts, Jessica Dennison

Abstract

Lutein and zeaxanthin are antioxidants found in the human retina and macula. Recent clinical trials have determined that age- and diet-related loss of lutein and zeaxanthin enhances phototoxic damage to the human eye and that supplementation of these carotenoids has a protective effect against photoinduced damage to the lens and the retina. Two of the major mechanisms of protection offered by lutein and zeaxanthin against age-related blue light damage are the quenching of singlet oxygen and other reactive oxygen species and the absorption of blue light. Determining the specific reactive intermediate(s) produced by a particular phototoxic ocular chromophore not only defines the mechanism of toxicity but can also later be used as a tool to prevent damage.

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Citations

Nov 17, 2016·International Journal of Retina and Vitreous·Verônica Castro LimaMichel Farah
Apr 2, 2020·Frontiers in Genetics·Edwige Gaby Nkouaya MbanjoNese Sreenivasulu
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Jul 10, 2021·Investigative Ophthalmology & Visual Science·Marina Green-GomezJohn Nolan
Aug 3, 2021·Experimental Eye Research·Tayler F L WishartFrank J Lovicu
Oct 26, 2021·The Science of the Total Environment·Callum RussellMohammed Yaseen

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