The photocurrent response of human cones is fast and monophasic.

BMC Neuroscience
J H van Hateren, T D Lamb

Abstract

The precise form of the light response of human cone photoreceptors in vivo has not been established with certainty. To investigate the response shape we compare the predictions of a recent model of transduction in primate cone photoreceptors with measurements extracted from human cones using the paired-flash electroretinogram method. As a check, we also compare the predictions with previous single-cell measurements of ground squirrel cone responses. The predictions of the model provide a good description of the measurements, using values of parameters within the range previously determined for primate retina. The dim-flash response peaks in about 20 ms, and flash responses at all intensities are essentially monophasic. Three time constants in the model are extremely short: the two time constants for inactivation (of visual pigment and of transducin/phosphodiesterase) are around 3 and 10 ms, and the time constant for calcium equilibration lies in the same range. The close correspondence between experiment and theory, using parameters previously derived for recordings from macaque retina, supports the notion that the electroretinogram approach and the modelling approach both provide an accurate estimate of the cone photoresponse...Continue Reading

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Citations

Apr 3, 2010·Biological cybernetics·Mikhail Y LipinW Rowland Taylor
Aug 2, 2008·Journal of Computational Neuroscience·Adrien Wohrer, Pierre Kornprobst
Jul 22, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Konstantin NikolicChris Toumazou
Nov 28, 2012·The Clinical Journal of Pain·Seiko MakinoMasako Hosoi
Feb 20, 2014·Proceedings of the National Academy of Sciences of the United States of America·Li-Hui CaoKing-Wai Yau
Nov 14, 2015·Eye·T D Lamb
May 6, 2015·Attention, Perception & Psychophysics·Ernest Greene, Adrienne Visani
Jun 12, 2014·Frontiers in Molecular Neuroscience·Xiao-Hong WenClint L Makino
Dec 17, 2009·The Journal of Physiology·D Endeman, M Kamermans
Mar 15, 2015·The Journal of Biological Chemistry·Teresa DudaClint L Makino
Dec 29, 2016·PloS One·Jihyun Yeonan-Kim, Marcelo Bertalmío
Sep 13, 2020·Science Advances·Vimal Prabhu PandiyanRamkumar Sabesan
Jul 9, 2021·Eye·Elisa E CornishJohn R Grigg

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