PMID: 7523029Jul 1, 1994Paper

The photodynamic occlusion of choroidal vessels using benzoporphyrin derivative

Current Eye Research
S C LinC A Puliafito

Abstract

We used benzoporphyrin derivative-monoacid (BPD-MA), a new photosensitizing agent, in photodynamic therapy (PDT) to occlude choroidal vessels in the rabbit. Using BPD-MA, seven dutch-belted rabbit eyes were photodynamically treated to achieve acute choroidal vessel closure. Fundoscopy, fluorescein angiography (FA), and histology were performed 1 hour, 1 day, 3 days, 7 days, 14 days, 21 days, and 28 days after PDT. On FA, PDT-treated spots remained nonperfused until day 3 when gradual reperfusion from the periphery began to appear. By day 28 the area of PDT appeared completely reperfused. Histology of lesions showed acute damage to choroidal vascular endothelial cells and retinal pigment epithelial (RPE) cells. Over subsequent days, recovery of RPE cells and regeneration of large choroidal vascular endothelial cells occurred. In addition, retinal degeneration occurred gradually over the 28 days of follow-up. Since current argon laser therapy of retinal neovascularization causes immediate retinal damage, the ability to occlude choroidal vessels without inducing acute thermal damage holds promise for treating clinical pathologic conditions that feature abnormal neovascularization, such as age-related macular degeneration and diabe...Continue Reading

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Citations

Jan 23, 2004·The British Journal of Ophthalmology·F GeliskenK U Bartz-Schmidt
Apr 8, 1998·BMJ : British Medical Journal·S G Bown
Jun 3, 2006·Photochemistry and Photobiology·Robert W Redmond, Irene E Kochevar
Jun 9, 2004·American Journal of Ophthalmology·Mehryar TabanMehran Taban
Jul 13, 2002·Lasers in Surgery and Medicine·Akira Obana, Yuko Gohto
Jan 21, 2010·Pharmaceutical Research·Denise BechetMuriel Barberi-Heyob
Jan 11, 2020·Social Cognitive and Affective Neuroscience·Takahiko KoikeNorihiro Sadato
May 21, 1999·The European Journal of Neuroscience·S Baron-CohenS C Williams
Jun 5, 2001·Current Opinion in Ophthalmology·M F ShulerA C Ho
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Mar 18, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Ami KlinFred Volkmar
Feb 1, 1997·Current Eye Research·R HaimoviciE S Gragoudas
Oct 8, 1998·Survey of Ophthalmology·T A CiullaA Harris

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