The photopic negative response of flash ERG in nonproliferative diabetic retinopathy.

Documenta Ophthalmologica. Advances in Ophthalmology
Hongling ChenDezheng Wu

Abstract

To test how the PhNR of the flash ERG is affected in human nonproliferative diabetic retinopathy (NPDR). The PhNR was elicited with red stimuli (5 cd s/m(2) with 4-min duration) and blue background (10 cd/m(2)). Standard Ganzfeld flash ERGs were recorded according to the ISCEV standard for the clinical electroretinogram (2004). A total of 81 diabetic patients with different severity levels of NPDR were examined. Forty-three age-matched normal controls were also studied. The amplitude of PhNR decreased significantly as DR progressed, while the implicit time was prolonged. Amplitudes of the PhNR in the control group, no DR, mild NPDR, moderate NPDR, and severe NPDR were 78.1 +/- 15.1 microV, 69.0 +/- 17.8 microV, 64.5 +/- 13.2 microV, 45.9 +/- 9.0 microV, and 33.7 +/- 10.8 muV respectively, and the implicit times of PhNR were 71.5 +/- 5.0, 72.0 +/- 6.2, 73.6 +/- 5.0, 75.7 +/- 6.1, and 82.9 +/- 7.8 min respectively. Compared to the control group, the reduction of PhNR amplitude in all diabetic groups was statistically significant. However, except for the OPs, the percent reduction of the amplitude of standard ERG waves was far less than that of the PhNR. The percent decrease in amplitude of the PhNR and summation OPs was not signi...Continue Reading

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Citations

Apr 25, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jenny C Y LungHenry H L Chan
Jun 1, 2011·Journal of Ocular Biology, Diseases, and Informatics·Vickie H Y WongBang V Bui
Jun 30, 2015·Cellular and Molecular Neurobiology·Chanjuan ZhangDaxiang Lu
Jun 16, 2015·Journal of Diabetes Research·Nicola PescosolidoGiuseppe Buomprisco
Nov 7, 2014·Translational Vision Science & Technology·Jessica TangMarc Sarossy
May 18, 2016·PloS One·Jenny C Y LungHenry H L Chan
Mar 24, 2017·Scientific Reports·Jason C ParkJ Jason McAnany
Oct 2, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Gonzalo OrtizRadouil Tzekov
Mar 28, 2012·Retina·Muneeswar G NittalaTarun Sharma
Jan 9, 2019·Translational Vision Science & Technology·Flora HuiJonathan G Crowston
May 17, 2017·Documenta Ophthalmologica. Advances in Ophthalmology·Nabin R JoshiSuresh Viswanathan
Jun 2, 2018·Documenta Ophthalmologica. Advances in Ophthalmology·Laura FrishmanSuresh Viswanathan
Apr 25, 2019·Documenta Ophthalmologica. Advances in Ophthalmology·Jason C ParkJ Jason McAnany
Dec 31, 2016·Documenta Ophthalmologica. Advances in Ophthalmology·Anthony W Van Alstine, Suresh Viswanathan
Jun 13, 2021·Eye·Oliver R Marmoy, Suresh Viswanathan
May 13, 2021·Diabetes·Priyamvada M PitaleMarina S Gorbatyuk

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