The phototoxicity of vemurafenib: An investigation of clinical monochromator phototesting and in vitro phototoxicity testing

Journal of Photochemistry and Photobiology. B, Biology
J A WoodsJ Ferguson

Abstract

Vemurafenib is a targeted therapy approved for the treatment of patients with metastatic melanoma harbouring the BRAF V600E mutation. Photosensitivity has been reported in over 50% of patients and has been demonstrated to involve at least the broadband UVA spectrum in most patients. Erythrocyte protoporphyrin levels have also been reported as elevated in some patients. We report the results of monochromator phototesting in one patient recorded before and while taking vemurafenib. Analysis of porphyrin levels was also conducted. After one month of vemurafenib therapy the patient demonstrated markedly increased light sensitivity in the UVA spectrum between 335 ± 27 nm, 365 ± 27 nm and 400 ± 27 nm. However responses in the UVB (305 ± 5 nm) and blue light (430 ± 27 nm) regions were normal. There was no abnormal immediate erythemal response. Pre-vemurafenib baseline phototesting was normal, as was repeat testing two months later when the patient was taking high doses of systemic steroid. No abnormal porphyrins were detected and the antinuclear antibody test was normal. In parallel studies, HaCaT keratinocytes incubated with vemurafenib were killed by UVA but not by visible (blue) light and did not show evidence of detectable intrace...Continue Reading

References

Nov 1, 1990·Journal of Photochemistry and Photobiology. B, Biology·J ScottK R Downum
May 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·C K Lim, T J Peters
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
May 12, 2000·Toxicology in Vitro : an International Journal Published in Association with BIBRA·N J TraynorN K Gibbs
Jun 29, 2001·Journal of Clinical Pathology·A C Deacon, G H Elder
Sep 14, 2001·Photodermatology, Photoimmunology & Photomedicine·H Moseley
Nov 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Johan W JonkerAlfred H Schinkel
Jan 13, 2009·Advanced Drug Delivery Reviews·Robert W RobeySusan E Bates
May 15, 2009·Photodermatology, Photoimmunology & Photomedicine·F M MullerJ Ferguson
Jan 15, 2010·Photodermatology, Photoimmunology & Photomedicine·Harry Moseley, James Ferguson
Mar 17, 2010·Photodiagnosis and Photodynamic Therapy·Sally H Ibbotson
Jun 7, 2011·The New England Journal of Medicine·Paul B ChapmanUNKNOWN BRIM-3 Study Group
Feb 3, 2012·The New England Journal of Medicine·Reinhard DummerSimone M Goldinger
Mar 29, 2012·The Journal of Pharmacology and Experimental Therapeutics·Rajendar K MittapalliWilliam F Elmquist
Feb 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L BoussemartC Robert
Mar 27, 2013·Experimental Dermatology·Pauline GelotBrigitte Dréno
May 24, 2013·JAMA Dermatology·Lise BoussemartCaroline Robert
Aug 6, 2013·Journal of Photochemistry and Photobiology. B, Biology·Gemma A BarronJulie A Woods
Jan 8, 2014·Photodermatology, Photoimmunology & Photomedicine·Susan M O'Gorman, Gillian M Murphy
Jan 15, 2014·Acta Paediatrica·Ronald J WongDavid K Stevenson

❮ Previous
Next ❯

Citations

Oct 5, 2018·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Sally Ibbotson
Oct 17, 2019·Photodermatology, Photoimmunology & Photomedicine·Markus V HepptMarkus Reinholz
May 19, 2018·Angewandte Chemie·Quan-Quan ZhouWen-Jing Xiao
Mar 21, 2020·Current Treatment Options in Oncology·Subashini Sharon GnanendranAndrew Charles Miller
Jun 20, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bernadette EberleinChristian Posch
Oct 29, 2020·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Bernadette EberleinChristian Posch
Apr 4, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Abdulilah Dawoud Bani-Yaseen
Jul 3, 2021·Cancers·Petra Dunkel, Janez Ilaš
Jun 21, 2020·Biochemical Pharmacology·Letícia Silva FerrazTiago Rodrigues

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The New England Journal of Medicine
Hiroyuki Morita, Ryozo Nagai
The New England Journal of Medicine
Stéphane DalleLuc Thomas
The New England Journal of Medicine
Jason P Lott
© 2021 Meta ULC. All rights reserved