The Phylogeny of Osteopontin-Analysis of the Protein Sequence

International Journal of Molecular Sciences
Georg F Weber

Abstract

Osteopontin (OPN) is important for tissue remodeling, cellular immune responses, and calcium homeostasis in milk and urine. In pathophysiology, the biomolecule contributes to the progression of multiple cancers. Phylogenetic analysis of 202 osteopontin protein sequences identifies a core block of integrin-binding sites in the center of the protein, which is well conserved. Remarkably, the length of this block varies among species, resulting in differing distances between motifs within. The amino acid sequence SSEE is a candidate phosphorylation site. Two copies of it reside in the far N-terminus and are variably affected by alternative splicing in humans. Between those motifs, birds and reptiles have a histidine-rich domain, which is absent from other species. Just downstream from the thrombin cleavage site, the common motif (Q/I)(Y/S/V)(P/H/Y)D(A/V)(T/S)EED(L/E)(-/S)T has been hitherto unrecognized. While well preserved, it is yet without assigned function. The far C-terminus, although very different between Reptilia/Aves on the one hand and Mammals on the other, is highly conserved within each group of species, suggesting important functional roles that remain to be mapped. Taxonomic variations in the osteopontin sequence inc...Continue Reading

Citations

May 29, 2021·Frontiers in Genetics·Nathalie Le RoyMaxwell T Hincke
Jun 3, 2021·Biomolecules·Gulimirerouzi FnuGeorg F Weber
Aug 8, 2021·Journal of Clinical Medicine·Angela Quispe-Salcedo, Hayato Ohshima
Sep 7, 2021·Frontiers in Genetics·Xia Wang, Georg F Weber

❮ Previous
Next ❯

Software Mentioned

MEME ( Multiple Em for Motif Elicitation
BioNJ
BLASTP
MEGA ( Molecular Evolutionary Genetics Analysis )
Clustal Omega
MOTIF
Meme Suite
ELM
GLAM2 ( Alignment of

Related Concepts

Related Feeds

Alternative splicing

Alternative splicing a regulated gene expression process that allows a single genetic sequence to code for multiple proteins. Here is that latest research.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

© 2022 Meta ULC. All rights reserved