The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate

Current Topics in Developmental Biology
Jonathon M Muncie, Valerie M Weaver

Abstract

The extracellular matrix is a complex network of hydrated macromolecular proteins and sugars that, in concert with bound soluble factors, comprise the acellular stromal microenvironment of tissues. Rather than merely providing structural information to cells, the extracellular matrix plays an instructive role in development and is critical for the maintenance of tissue homeostasis. In this chapter, we review the composition of the extracellular matrix and summarize data illustrating its importance in embryogenesis, tissue-specific development, and stem cell differentiation. We discuss how the biophysical and biochemical properties of the extracellular matrix ligate specific transmembrane receptors to activate intracellular signaling that alter cell shape and cytoskeletal dynamics to modulate cell growth and viability, and direct cell migration and cell fate. We present examples describing how the extracellular matrix functions as a highly complex physical and chemical entity that regulates tissue organization and cell behavior through a dynamic and reciprocal dialogue with the cellular constituents of the tissue. We suggest that the extracellular matrix not only transmits cellular and tissue-level force to shape development and...Continue Reading

Citations

Jan 31, 2019·Biomedical Materials·Stefanie KorntnerDimitrios I Zeugolis
Aug 30, 2019·Essays in Biochemistry·Isra N Taha, Alexandra Naba
Jun 22, 2019·Biochemistry. Biokhimii︠a︡·E S NovoseletskayaN I Kalinina
Apr 4, 2020·Tissue Engineering. Part B, Reviews·Sze Wing TangYun Wah Lam
Sep 11, 2019·Biophysics Reviews·Ece BayirYannis F Missirlis
Jan 4, 2019·Tissue Engineering and Regenerative Medicine·Kyung Min Park, Ki Dong Park
Mar 7, 2020·Frontiers in Bioengineering and Biotechnology·Elif Nur Yilmaz, Dimitrios I Zeugolis
May 30, 2020·Development·David A Cruz Walma, Kenneth M Yamada
May 30, 2020·Cells·Natividad Alcorta-SevillanoArantza Infante
Jan 15, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Keui-Yu ChaoTzu-Wei Wang
Jan 14, 2021·Journal of Cellular Biochemistry·Carina MagdalenoArchana Varadaraj
Feb 2, 2021·ACS Biomaterials Science & Engineering·Ross C Bretherton, Cole A DeForest
Feb 18, 2021·Trends in Biotechnology·Nathaniel F C HenningMonica M Laronda
Feb 10, 2021·Current Biology : CB·Duy-Chi TrinhOlivier Hamant
Feb 7, 2021·International Journal of Oral Science·Wei DuJimmy K Hu
Nov 25, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Andrea RaspaFabrizio Gelain
Mar 15, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Shikun ZhangLing Leng
Mar 19, 2021·Journal of Experimental & Clinical Cancer Research : CR·Sheila SpadaPaola Nisticò
Mar 9, 2021·Frontiers in Bioengineering and Biotechnology·Pauline MaurySandrine Lacombe
Mar 31, 2021·Npj Regenerative Medicine·Andrea De PieriDimitrios I Zeugolis
Mar 30, 2021·Progress in Polymer Science·Xuan MuDavid L Kaplan
Apr 4, 2021·Brain Research·Pearl A SutterStephen J Crocker
May 1, 2021·International Journal of Molecular Sciences·Sabah NisarMuzafar A Macha
Apr 13, 2021·Molecular & Cellular Proteomics : MCP·Maxwell C McCabeKirk C Hansen
Jun 3, 2021·International Journal of Molecular Sciences·Ivan ZhivodernikovLudmila Buravkova
Jun 29, 2021·IScience·Ting-Xin JiangCheng-Ming Chuong
Jun 15, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yu-Ting TsengJenny Ekberg
Jul 15, 2021·Developmental Cell·Gat Rauner, Charlotte Kuperwasser

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Cell Signaling by Tyrosine Kinases

Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. RTKs have been shown not only to be key regulators of normal cellular processes but also to have a critical role in the development and progression of many types of cancer. Discover the latest research on cell signaling and RTK here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Related Papers

Current Opinion in Genetics & Development
William P Daley, Kenneth M Yamada
Journal of Biomedical Materials Research. Part a
Shawn C Owen, Molly S Shoichet
© 2022 Meta ULC. All rights reserved