The physical basis of renal fibrosis: effects of altered hydrodynamic forces on kidney homeostasis

American Journal of Physiology. Renal Physiology
Bryan M Grabias, Konstantinos Konstantopoulos

Abstract

Healthy kidneys are continuously exposed to an array of physical forces as they filter the blood: shear stress along the inner lumen of the tubules, distension of the tubular walls in response to changing fluid pressures, and bending moments along both the cilia and microvilli of individual epithelial cells that comprise the tubules. Dysregulation of kidney homeostasis via underlying medical conditions such as hypertension, diabetes, or glomerulonephritis fundamentally elevates the magnitudes of each principle force in the kidney and leads to fibrotic scarring and eventual loss of organ function. The purpose of this review is to summarize the progress made characterizing the response of kidney cells to pathological levels of mechanical stimuli. In particular, we examine important, mechanically responsive signaling cascades and explore fundamental changes in renal cell homeostasis after cyclic strain or fluid shear stress exposure. Elucidating the effects of these disease-related mechanical imbalances on endogenous signaling events in kidney cells presents a unique opportunity to better understand the fibrotic process.

References

Jan 1, 1991·The American Journal of Physiology·D Filipovic, H Sackin
Feb 1, 1991·Stroke; a Journal of Cerebral Circulation·C C TijssenA C Leyten
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·S M WahlM B Sporn
Oct 23, 1986·The New England Journal of Medicine·P L LudmerP Ganz
Jul 1, 1974·Kidney International·J M KaufmanJ P Hayslett
Dec 1, 1970·Human Pathology·L I SchainuckE P Benditt
Jul 1, 1981·The American Journal of Physiology·T H HostetterB M Brenner
Dec 15, 1994·Biochemical and Biophysical Research Communications·Y TakadaJ Ando
Apr 1, 1996·Journal of Occupational and Environmental Medicine·C S MitchellB S Schwartz
Jan 1, 1997·Annual Review of Physiology·J Sadoshima, S Izumo
Apr 1, 1997·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M Kitamura, T S Sütö
Jun 1, 1997·The American Journal of Physiology·S D RicardoJ R Diamond
Dec 10, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·P StenvinkelC G Elinder
Aug 5, 2000·American Journal of Physiology. Renal Physiology·Z CaiJ S Pollock
Sep 21, 2000·American Journal of Physiology. Renal Physiology·P GuoS Weinbaum
Dec 29, 2000·Seminars in Thrombosis and Hemostasis·P L Gross, W C Aird
Feb 22, 2001·American Journal of Physiology. Renal Physiology·B Y ChinM E Choi
Jun 8, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C H BoltonJ H Pinkney
Aug 14, 2001·Renal Failure·V PanichiR Palla
Sep 13, 2001·American Journal of Physiology. Renal Physiology·M EssigG Friedlander
Mar 29, 2002·American Journal of Nephrology·Stefan H JacobsonJoachim Lundahl
Apr 23, 2002·Kidney International·Katsuyuki NagatoyaMasatsugu Hori
Aug 9, 2002·American Journal of Physiology. Renal Physiology·Craig B WodaLisa M Satlin
Aug 31, 2002·Scandinavian Journal of Urology and Nephrology·T S PedersenJ Frøkiaer
Apr 23, 2003·European Journal of Pharmacology·Maki SaitoKoichi Nakayama
Jul 3, 2003·American Journal of Physiology. Renal Physiology·Wen LiuLisa M Satlin
Sep 25, 2003·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Masaaki YoshigiH Joseph Yost
Jan 14, 2004·Kidney International·Larry D AlexanderJanice G Douglas

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Citations

Feb 11, 2015·Journal of Applied Toxicology : JAT·Marie-Hélène AntoineJoëlle L Nortier
Jul 7, 2015·PloS One·Damien MaggioraniBénédicte Buffin-Meyer
Jul 8, 2016·Clinical and Experimental Pharmacology & Physiology·Debra FongRoger G Evans
Feb 21, 2018·Biotechnology and Bioengineering·Jose YesteIgnacio Giménez
Oct 19, 2017·Journal of Cellular Physiology·Steven J KunnenDorien J M Peters
May 20, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Radica Z AlicicKatherine R Tuttle
Jul 10, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Craig E HigginsPaul J Higgins
Jan 8, 2016·American Journal of Physiology. Renal Physiology·Angara SureshbabuMary E Choi
Mar 15, 2019·Scientific Reports·Janne Folke BialikAndrás Kapus
Dec 15, 2019·Nature Communications·David M BarryShahin Rafii
Oct 10, 2020·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Yiru WangYukun Luo
May 1, 2021·Journal of Clinical Medicine·Nestor Oliva-DamasoAndrew S Bomback
May 25, 2021·Frontiers in Physiology·Bao-Yi ShaoHai-Yong Chen
Jun 3, 2021·International Journal of Molecular Sciences·Sindhu NaikKai S Erdmann
Aug 18, 2021·BMC Medicine·Mohamad HanounehBernard G Jaar

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