PMID: 9432065Jan 31, 1998Paper

The physiologic reservoir of Epstein-Barr virus does not map to upper aerodigestive tissues

The Laryngoscope
P G LiavaagH M Dosch

Abstract

The human Epstein-Barr herpesvirus (EBV) has distinct oncogenic potential, but with over 90% of the adult world population infected, malignancy is a rare outcome of carrier status. However, EBV's association with over half of Hodgkin's and non-Hodgkin's lymphomas as well as several solid tumors, notably nasopharyngeal carcinoma, makes EBV-linked malignancies one of the largest single cancer entities. EBV is a B-lymphotropic virus, well controlled by surveillant T cells in immunocompetent hosts. To determine the presence and site of principal virus reservoirs is a likely prerequisite for understanding the etiology of EBV-associated tumors. Its near 100% association with nasopharyngeal carcinoma led to postulates that the upper aerodigestive tract tissue may be common sites of persistent latent or low-grade replicating infection. Using a protocol designed to avoid viral crosscontamination, the authors employed polymerase chain reaction to detect genomic EBV DNA sequences in 231 biopsies from different mucosal sites in the upper aerodigestive tract, as well as from salivary gland tissue and neck nodes in individuals not suspected to have EBV-related malignancy. Only two samples, one from oral cavity mucosa and one from parotid gla...Continue Reading

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Citations

May 10, 2002·Head & Neck·Christina J LaaneAnil K Lalwani
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Sheng-Po HaoShir-Hwa Ueng
Aug 31, 2004·Japanese Journal of Clinical Oncology·Smriti M KrishnaPrabha Balaram
May 18, 1999·Journal of the National Cancer Institute·C E TuneH M Dosch
Nov 25, 2000·Molecular Pathology : MP·G Niedobitek
Aug 8, 2006·American Journal of Clinical Pathology·Deilson Elgui de OliveiraCarlos E Bacchi
Mar 1, 2005·Journal of Periodontal Research·Işil SaygunJørgen Slots
Apr 21, 2005·Microbes and Infection·Shih-Shen LinChi-Chiang Yang

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