The physiological and clinical importance of sodium potassium ATPase in cardiovascular diseases

Current Opinion in Pharmacology
Yanling Yan, Joseph I Shapiro

Abstract

The Na/K-ATPase has been extensively studied, but it is only recently that its role as a scaffolding and signaling protein has been identified. It has been identified that cardiotonic steroids (CTS) such as digitalis mediate signal transduction through the Na/K-ATPase in a process found to result in the generation of reactive oxygen species (ROS). As these ROS also appear capable of initiating this signal cascade, a feed forward amplification process has been postulated and subsequently implicated in some disease pathways including uremic cardiomyopathy.

References

Sep 1, 1987·The Journal of Clinical Investigation·M NakamotoR W Schrier
Jan 1, 1988·Nephron·J D HarnettR D Guttmann
Jun 1, 1984·Proceedings of the Society for Experimental Biology and Medicine·M B PamnaniF J Haddy
May 17, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·M M MitsnefesC F Strife
Oct 10, 2002·Kidney International·Jonathan HimmelfarbRaymond M Hakim
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Austin G Stack, Rajiv Saran
Feb 14, 2004·The Journal of Biological Chemistry·Haojie WangZijian Xie
Apr 21, 2005·Kidney International·Sankaridrug M PeriyasamyJoseph I Shapiro
Jun 25, 2005·Molecular Biology of the Cell·Zhaokan YuanZijian Xie
Jun 1, 2006·Acta Physiologica·R T Alexander, S Grinstein
Jul 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·David J KennedyJoseph I Shapiro
Oct 19, 2006·Free Radical Biology & Medicine·Lijun LiuZijian Xie
Feb 3, 2007·Cell Biochemistry and Biophysics·Sandrine V Pierre, Zijian Xie
Oct 27, 2007·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Jiang Liu, Joseph I Shapiro
Jun 11, 2008·Nature Clinical Practice. Nephrology·Alexei Y Bagrov, Joseph I Shapiro
Aug 13, 2008·Current Opinion in Nephrology and Hypertension·Käthi Geering
Mar 28, 2009·Pharmacological Reviews·Alexei Y BagrovOlga V Fedorova
Mar 30, 2010·Biochimica Et Biophysica Acta·Olga V FedorovaAlexei Y Bagrov
May 11, 2011·The Journal of Biological Chemistry·Jiang LiuJoseph I Shapiro
Jul 26, 2011·The Journal of Biological Chemistry·Zhichuan LiZijian Xie
Apr 21, 2012·International Journal of Nephrology·Jiang LiuJoseph I Shapiro
May 24, 2012·Molecular and Cellular Biochemistry·Yanling YanJiang Liu
May 16, 2013·Journal of Molecular and Cellular Cardiology·Davor PavlovicMichael J Shattock
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Mette LaursenNatalya U Fedosova
Sep 21, 2013·Science·Maria NyblomPoul Nissen
Nov 14, 2013·Current Clinical Pharmacology·Larry DialJoseph I Shapiro
Feb 11, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Silvia BaecherMichael Vogeser
Mar 29, 2014·Biochemical and Biophysical Research Communications·Marjorie E GableAmir Askari
Feb 18, 2015·Biochimica Et Biophysica Acta·Mikael EsmannClaus Olesen

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Citations

Sep 7, 2016·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Krithika SrikanthanKomal Sodhi
Mar 8, 2018·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Christian StaehrVladimir V Matchkov
Mar 3, 2020·Free Radical Research·Le Ba Nam, Young-Sam Keum
Sep 10, 2019·Archives of Physiology and Biochemistry·Sandeep SinghSyed Ibrahim Rizvi
Nov 12, 2019·Cardiovascular Research·Christian StaehrVladimir V Matchkov
Dec 28, 2019·International Journal of Molecular Sciences·Rebecca PrattKomal Sodhi
May 21, 2020·The Journal of Membrane Biology·Jyoti Kumari, Mangal S Rathore
Jul 26, 2018·International Journal of Molecular Sciences·David E BartlettKomal Sodhi
Aug 6, 2020·Toxins·Andrea Boente-JuncalLuis M Botana
May 23, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Xi ChengYu Wang
Sep 12, 2018·International Journal of Molecular Sciences·David E BartlettKomal Sodhi
Jul 19, 2019·International Journal of Molecular Sciences·Yanling YanJiang Liu
Aug 28, 2020·Archives of Oral Biology·Raquel Cristine Silva BarcelosCarlos Alexandre de Souza Bier

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