The physiological effects of IGF-1 (class 1:Ea transgene) over-expression on exercise-induced damage and adaptation in dystrophic muscles of mdx mice.

Pflügers Archiv : European journal of physiology
James A RidgleyMiranda D Grounds

Abstract

Duchenne muscular dystrophy (DMD) is a genetic disorder in which muscle weakness and fragility contribute to ongoing muscle degeneration. Although exercise-induced muscle damage is associated with adaptation that protects normal muscle from further damage, exploiting this process to protect dystrophic muscle has been avoided for fear of inducing excessive muscle degeneration. However, muscle-specific over-expression of the class 1:Ea isoform of insulin-like growth factor-1 (IGF-1) reduces myofibre necrosis in dystrophic mdx mice (a model for DMD) and, therefore, may enhance the adaptation process in response to eccentric exercise. To test this hypothesis, we evaluated the effect of transgenic class 1:Ea IGF-1 over-expression on the susceptibility to muscle damage and subsequent adaptation in 12-week-old dystrophic mdx and non-dystrophic control mice. Experiments were conducted in vivo using a custom-built isokinetic mouse dynamometer to measure the deficit in joint torque (indicating muscle damage) after 20 maximal lengthening (eccentric) contractions. Adaptation to this damaging exercise was evaluated by repeating the protocol 7 days after the initial exercise. The over-expression of IGF-1 significantly increased the normalise...Continue Reading

References

Mar 1, 1992·Journal of Applied Physiology·J A Ashton-MillerJ A Faulkner
Jul 1, 1995·Neuromuscular Disorders : NMD·G T CarterW M Fowler
Oct 1, 1994·Journal of Applied Physiology·E E Dupont-VersteegdenM S Katz
Nov 1, 1993·Journal of the Neurological Sciences·J K McGeachieJ E Morgan
Mar 3, 1998·American Journal of Physical Medicine & Rehabilitation·M A WineingerG T Carter
Apr 16, 1998·Journal of Muscle Research and Cell Motility·S V Brooks
Mar 17, 2001·Scandinavian Journal of Medicine & Science in Sports·J Fridén, R L Lieber
Apr 3, 2002·The Journal of Cell Biology·Elisabeth R BartonH Lee Sweeney
Sep 19, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Gordon L WarrenPetia P Simeonova
Nov 8, 2002·Archives of Physical Medicine and Rehabilitation·Martin K ChildersJoe N Kornegay
Dec 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Annamaria De LucaDiana Conte Camerino
Mar 29, 2003·British Journal of Sports Medicine·N GleesonM McHugh
Jun 14, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Tor Ansved
Oct 29, 2004·Molecular Therapy : the Journal of the American Society of Gene Therapy·Thea ShavlakadzeMiranda D Grounds
Feb 8, 2005·Neuromuscular Disorders : NMD·Thea ShavlakadzeMiranda D Grounds
Feb 11, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Thea ShavlakadzeMiranda D Grounds
Apr 15, 2005·Journal of Applied Physiology·James G Tidball
Nov 19, 2005·Scandinavian Journal of Medicine & Science in Sports·M D GroundsJ White
May 24, 2006·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·T ShavlakadzeC Goddard
Jun 23, 2006·Clinical and Experimental Pharmacology & Physiology·Nicholas P WhiteheadDavid G Allen
Dec 23, 2006·European Journal of Applied Physiology·J E GregoryU Proske
Jan 11, 2007·Exercise and Sport Sciences Reviews·Robert W Grange, Jarrod A Call
Nov 9, 2007·American Journal of Physiology. Cell Physiology·Jonathan D SchertzerGordon S Lynch
Jan 22, 2008·Neuromuscular Disorders : NMD·Hannah G RadleyMiranda D Grounds
Jan 25, 2008·Clinical and Experimental Pharmacology & Physiology·Miranda D GroundsThea Shavlakadze

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Citations

Oct 1, 2011·Journal of Applied Physiology·Jarrod A CallDawn A Lowe
Oct 22, 2013·Neuromuscular Disorders : NMD·Valérie DecostreJean-Yves Hogrel
Apr 24, 2018·Journal of Cachexia, Sarcopenia and Muscle·Pietro SpitaliAnnemieke Aartsma-Rus
May 28, 2019·Frontiers in Physiology·Stéphanie HodyPierre Leprince

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