PMID: 9193146Jan 1, 1997Paper

The physiological effects of serotonin on spontaneous and amino acid-induced activation of cerebellar nuclear cells: an in vivo study in the cat

Progress in Brain Research
P H Kitzman, G A Bishop

Abstract

It is well established that cerebellar efferents originate from neurons located within the cerebellar nuclei. Neurons within these nuclei receive excitatory inputs derived from the axons that arise from cells in several different regions of the brainstem and spinal cord, some of which continue on to terminate as mossy fibers and climbing fibers in the cerebellar cortex. GABA-induced inhibition in the nuclei is derived primarily from Purkinje cells located in the overlying cortex and possibly from axonal collaterals of a population of small, GABAergic nuclear neurons. In addition, a third chemically defined system of afferents that contain the monoamine serotonin forms a dense plexus of fibers throughout the cat's cerebellar nuclei. The intent of this study is to determine the physiological effects of serotonin on the spontaneous activity of cerebellar nuclear cells as well as that induced by application of the excitatory amino acids glutamate and aspartate in an adult in vivo preparation. Iontophoretic application of serotonin in anesthetized preparations suppresses both spontaneous and excitatory amino acid induced activity. In addition, interactions between serotonin and the amino acid analogs quisqualate and NMDA were analyz...Continue Reading

Citations

Aug 14, 2001·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·S Dieudonné
Jun 19, 2002·Integrative Physiological and Behavioral Science : the Official Journal of the Pavlovian Society·Thomas R Minor, Aimee M Hunter
Oct 23, 2013·Pflügers Archiv : European journal of physiology·Chang-Zheng ZhangJian-Jun Wang
Jul 23, 2003·Neuroscience Letters·Michela Di MauroFrancesca Santangelo
Jul 2, 2021·Frontiers in Neural Circuits·Moritoshi HironoYuchio Yanagawa
Aug 24, 2021·Frontiers in Systems Neuroscience·Paolo FlaceGiuseppe Anastasi

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