The physiological effects of transcranial electrical stimulation do not apply to parameters commonly used in studies of cognitive neuromodulation

Neuropsychologia
Beth L ParkinVincent Walsh

Abstract

Transcranial direct current stimulation (tDCS) and transcranial random noise stimulation (tRNS) have been claimed to produce many remarkable enhancements in perception, cognition, learning and numerous clinical conditions. The physiological basis of the claims for tDCS rests on the finding that 1 mA of unilateral anodal stimulation increases cortical excitation and 1 mA of cathodal produces inhibition. Here we show that these classic excitatory and inhibitory effects do not hold for the bilateral stimulation or 2 mA intensity conditions favoured in cognitive enhancement experiments. This is important because many, including some of the most salient claims are based on experiments using 2 mA bilateral stimulation. The claims for tRNS are also based on unilateral stimulation. Here we show that, again the classic excitatory effects of unilateral tRNS do not extend to the bilateral stimulation preferred in enhancement experiments. Further, we show that the effects of unilateral tRNS do not hold when one merely doubles the stimulation duration. We are forced to two conclusions: (i) that even if all the data on TES enhancements are true, the physiological explanations on which the claims are based are at best not established but at w...Continue Reading

Citations

Nov 19, 2019·Journal of Neural Engineering·Siddharth Kohli, Alexander J Casson
Jun 13, 2020·Journal of Cognitive Neuroscience·Til Ole Bergmann, Gesa Hartwigsen
Dec 18, 2019·The European Journal of Neuroscience·J G WrightsonG Y Millet
Nov 30, 2018·Scientific Reports·Zsolt TuriMatthias Mittner
Jan 23, 2019·Frontiers in Neuroscience·Sheida RabipourFrançois Tremblay
May 1, 2019·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Camilla L NordJonathan P Roiser
May 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yiheng TuJian Kong

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