The physiological role of endoglin in the cardiovascular system

American Journal of Physiology. Heart and Circulatory Physiology
José M López-Novoa, Carmelo Bernabeu

Abstract

Endoglin (CD105) is an integral membrane glycoprotein that serves as a coreceptor for members of the transforming growth factor-β superfamily of proteins. A major role for endoglin in regulating transforming growth factor-β-dependent vascular remodeling and angiogenesis has been postulated based on the following: 1) endoglin is the gene mutated in hereditary hemorrhagic telangiectasia type 1, a disease characterized by vascular malformations; 2) endoglin knockout mice die at midgestation because of defective angiogenesis; 3) endoglin is overexpressed in neoangiogenic vessels, during inflammation, and in solid tumors; and 4) endoglin regulates the expression and activity of endothelial nitric oxide synthase, which is involved in angiogenesis and vascular tone. Besides the predominant form of the endoglin receptor (long endoglin isoform), two additional forms of endoglin have been recently reported to play a role in the vascular pathology and homeostasis: the alternatively spliced short endoglin isoform and a soluble endoglin form that is proteolytically cleaved from membrane-bound endoglin. The purpose of this review is to underline the role that the different forms of endoglin play in regulating angiogenesis, vascular remodelin...Continue Reading

References

Feb 1, 1992·European Journal of Immunology·P LastresC Bernabeu
Oct 1, 1990·The Journal of Investigative Dermatology·I M BravermanB S Jacobson
Oct 5, 1995·The New England Journal of Medicine·A E GuttmacherR I White
Aug 1, 1994·The Biochemical Journal·P LastresC Bernabéu
Nov 1, 1993·American Journal of Obstetrics and Gynecology·C Yallampalli, R E Garfield
Jan 1, 1993·Cytogenetics and Cell Genetics·E Fernández-RuizC Bernabéu
Sep 1, 1995·Journal of Dermatological Science·H F RuloD J Ruiter
Jun 1, 1996·The Journal of Cell Biology·P LastresC Bernabéu
Apr 1, 1996·The Journal of Pathology·P KumarC Bernabeu
Apr 17, 1997·Nature·W Risau
Mar 14, 1998·Acta Dermato-venereologica·P C van de KerkhofE M De Jong
Jun 24, 1998·Biochemical and Biophysical Research Communications·P J AdamP L Weissberg
Nov 26, 1998·The Journal of Biological Chemistry·A LetamendíaC Bernabeu
May 4, 1999·International Journal of Cancer. Journal International Du Cancer·D W MillerJ Adamkiewicz
May 29, 1999·Science·D Y LiD P Wendel
Oct 27, 1999·European Journal of Cell Biology·M Guerrero-EsteoC Bernabéu
Nov 24, 1999·The Journal of Clinical Investigation·A BourdeauM Letarte
Jan 8, 2000·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·C LiS Kumar
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P OhE Li
Feb 7, 2001·International Journal of Cancer. Journal International Du Cancer·C LiS Kumar
Dec 18, 2001·Mechanisms of Development·Leon Jonker, Helen M Arthur
Apr 3, 2002·The EMBO Journal·Marie-José GoumansPeter ten Dijke
May 16, 2002·Biochimica Et Biophysica Acta·Luisa Diez-MarquesCarmelo Bernabeu
May 17, 2002·The Journal of Biological Chemistry·Mercedes Guerrero-EsteoCarmelo Bernabeu
Jun 14, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Chiwaka KimuraYushi Ito
Sep 14, 2002·The Journal of Biological Chemistry·Tilman Sánchez-ElsnerCarmelo Bernabéu
Oct 9, 2002·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·E TorsneyH M Arthur
Nov 2, 2002·Hypertension·Ana Rodríguez-PeñaJosé M López-Novoa

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Citations

Jan 25, 2013·European Journal of Nuclear Medicine and Molecular Imaging·Yin ZhangWeibo Cai
Nov 23, 2011·Cell and Tissue Research·Francisco J López-Hernández, Jose M López-Novoa
May 18, 2011·Circulation Journal : Official Journal of the Japanese Circulation Society·Zbynek StraskyPetr Nachtigal
Jan 24, 2013·PloS One·Mónica del ReyAlicia Rodríguez-Barbero
Oct 3, 2012·Vascular Health and Risk Management·Santiago RedondoTeresa Tejerina
May 11, 2013·Vascular Health and Risk Management·Navin K KapurMichelle Letarte
Dec 10, 2013·Advanced Drug Delivery Reviews·Fabian KiesslingTwan Lammers
Jun 8, 2014·Domestic Animal Endocrinology·G BasiniF Grasselli
Dec 3, 2014·Expert Reviews in Molecular Medicine·Jose M Muñoz-FelixJose M Lopez-Novoa
Nov 6, 2012·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Kunio KawanishiKosaku Nitta
Sep 13, 2014·Journal of Cellular Physiology·Francisco J BlancoCarmelo Bernabeu
Feb 12, 2013·Trends in Cardiovascular Medicine·Cecilia T CostiniukEdward R O'Brien
Mar 29, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jana RathouskaPetr Nachtigal
Jun 15, 2013·The Journal of Investigative Dermatology·Eduardo Pérez-GómezJosé M López-Novoa
Dec 10, 2015·Cellular and Molecular Life Sciences : CMLS·Elisa RossiCarmelo Bernabeu
Oct 27, 2015·Pharmacology & Therapeutics·José M Muñoz-FélixJosé M López-Novoa
Sep 9, 2015·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Nicola S RussellMarion Scharpfenecker
May 4, 2011·Birth Defects Research. Part A, Clinical and Molecular Teratology·Helen M Arthur, Simon D Bamforth
Aug 29, 2014·Journal of Cellular Biochemistry·Samaneh Ekhteraei-TousiMasoud Soleimani
May 28, 2013·Biochimica Et Biophysica Acta·María González-NúñezJosé M López-Novoa
Sep 24, 2013·Cytokine & Growth Factor Reviews·José M Muñoz-FélixJosé M López-Novoa
May 28, 2011·Clinical Science·Juan F SantibañezCarmelo Bernabeu
Nov 23, 2011·Biochemical Society Transactions·Marwa MahmoudHelen M Arthur
Mar 31, 2012·Atherosclerosis·Petr NachtigalZbynek Strasky

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