The physiological roles of autophagy in the mammalian life cycle

Biological Reviews of the Cambridge Philosophical Society
Liang WangTongbiao Zhao

Abstract

Autophagy is primarily an efficient intracellular catabolic pathway used for degradation of abnormal cellular protein aggregates and damaged organelles. Although autophagy was initially proposed to be a cellular stress responder, increasing evidence suggests that it carries out normal physiological roles in multiple biological processes. To date, autophagy has been identified in most organs and at many different developmental stages, indicating that it is not only essential for cellular homeostasis and renovation, but is also important for organ development. Herein, we summarize our current understanding of the functions of autophagy (which here refers to macroautophagy) in the mammalian life cycle.

References

Nov 23, 2000·European Journal of Cell Biology·H Takano-OhmuroK Morioka
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Zhenyu YueNathaniel Heintz
Jun 1, 2004·Journal of Cell Science·Yukiko KabeyaTamotsu Yoshimori
Nov 5, 2004·Nature·Akiko KumaNoboru Mizushima
Dec 8, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Flavia L LopesBruce D Murphy
May 4, 2005·The Journal of Cell Biology·Masaaki KomatsuTomoki Chiba
Sep 26, 2006·Nature Cell Biology·Shida YousefiHans-Uwe Simon
Apr 21, 2007·Science·Michael L Stitzel, Geraldine Seydoux
Jun 26, 2007·Nature·Gian Maria FimiaFrancesco Cecconi
Nov 8, 2007·The Journal of Biological Chemistry·Takao HanadaYoshinori Ohsumi
Nov 28, 2007·Annual Review of Pathology·Mondira Kundu, Craig B Thompson
Jan 12, 2008·Autophagy·Brian C MillerHerbert W Virgin
Mar 12, 2008·The Journal of Cell Biology·Enko N KiprilovRhoda Elison Hirsch
Apr 17, 2008·Journal of Structural Biology·Zhong-Ying ShenLi-Jun Tan
Jul 5, 2008·Science·Satoshi TsukamotoNoboru Mizushima
Oct 14, 2008·Autophagy·Satoshi TsukamotoNoboru Mizushima
Feb 13, 2009·Molecular Biology of the Cell·Nao HosokawaNoboru Mizushima
Feb 20, 2009·Molecular Biology of the Cell·Chang Hwa JungDo-Hyung Kim
Aug 6, 2009·Annual Review of Genetics·Congcong He, Daniel J Klionsky
Oct 27, 2009·Autophagy·Päivi Ylä-AnttilaEeva-Liisa Eskelinen
Nov 10, 2009·Nature Cell Biology·Mitsuko Hayashi-NishinoAkitsugu Yamamoto
Feb 13, 2010·Fertility and Sterility·Jong Yeob ChoiDoo Seok Choi
May 19, 2010·Cell·Dale W HaileyJennifer Lippincott-Schwartz
Jul 16, 2010·Fertility and Sterility·JongYeob ChoiDooSeok Choi
Oct 12, 2010·Autophagy·Nicholas T KtistakisJoshua Long
Oct 23, 2010·Molecular Cell·Shomit SenguptaDavid M Sabatini
Jan 25, 2011·Nature Cell Biology·Joungmok KimKun-Liang Guan
Feb 23, 2011·The Journal of Experimental Medicine·Monika MortensenAnna Katharina Simon
Mar 3, 2011·Endocrinology·Jong-Eun LeeHyunjung Jade Lim
Apr 6, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Thomas R GawrilukEdmund B Rucker
May 3, 2011·Cell Metabolism·Rajat Singh, Ana Maria Cuervo

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Citations

Jan 24, 2020·Molecular Cancer·Xiaohua LiBinyun Ma
Aug 11, 2020·Expert Review of Proteomics·Xingyun WuKui Wang
Jul 19, 2020·International Journal of Molecular Sciences·Janusz BlasiakKai Kaarniranta
Nov 3, 2020·The FEBS Journal·Harvey E Johnston, Rahul S Samant
Sep 10, 2020·Journal of Dermatological Science·Jonathan A HardmanRalf Paus
Nov 25, 2019·Tissue & Cell·Alexander V Kalachev, Olga V Yurchenko
Jan 9, 2021·Cancer Management and Research·Minmin WuJiadong Su
Dec 1, 2020·Frontiers in Cellular and Infection Microbiology·David R ThomasHayley J Newton
Mar 14, 2021·International Journal for Parasitology·Mudassar N MughalSimone Haeberlein
Apr 4, 2021·Cancers·Yi WuXian-Ping Dong
May 2, 2021·Cell Proliferation·Chaoqun WangTongbiao Zhao
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Shanshan ChenDi Wang

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Methods Mentioned

BETA
transmission electron microscopy

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