The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

PLoS Computational Biology
Rosanna MiglioreMichele Migliore

Abstract

Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal membrane, and the composition and spatial distribution of ion channels across its processes. For a variety of physiological or pathological reasons, the intrinsic input/output function may change during a neuron's lifetime. This process results in high variability in the peak specific conductance of ion channels in individual neurons. The mechanisms responsible for this variability are not well understood, although there are clear indications from experiments and modeling that degeneracy and correlation among multiple channels may be involved. Here, we studied this issue in biophysical models of hippocampal CA1 pyramidal neurons and interneurons. Using a unified data-driven simulation workflow and starting from a set of experimental recordings and morphological reconstructions obtained from rats, we built and analyzed several ensembles of morphologically and biophysically accurate single cell models with intrinsic electrophysiological properties consistent with experimental findin...Continue Reading

References

Jan 1, 1997·Annual Review of Physiology·N V Marrion
Jan 23, 1999·Journal of Neurophysiology·D A Hoffman, D Johnston
May 16, 2000·The Journal of Physiology·D JohnstonM Migliore
Nov 8, 2001·Proceedings of the National Academy of Sciences of the United States of America·G M Edelman, J A Gally
Dec 4, 2001·Journal of Neurophysiology·N L GoldingN Spruston
May 4, 2002·Nature Reviews. Neuroscience·Michele Migliore, Gordon M Shepherd
Jul 29, 2005·Journal of Neurophysiology·Jason N MacLeanRonald M Harris-Warrick
Nov 19, 2005·Journal of Neurophysiology·Michele MiglioreGiorgio A Ascoli
May 24, 2006·Progress in Neurobiology·Li-Lian Yuan, Xixi Chen
Jun 23, 2006·Nature Reviews. Neuroscience·Eve Marder, Jean-Marc Goaillard
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·David J SchulzEve E Marder
Jun 24, 2008·Nature Reviews. Neuroscience·UNKNOWN Petilla Interneuron Nomenclature GroupRafael Yuste
Jul 25, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Cengiz GünayDieter Jaeger
Jan 13, 2009·Neurobiology of Disease·Béatrice MarcelinChristophe Bernard
May 1, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Adam L TaylorEve Marder
May 7, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giorgio A AscoliMichele Migliore
Oct 7, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sangwook JungNicholas P Poolos
Sep 28, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shunbing Zhao, Jorge Golowasch
Feb 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Francesco MiceliMaurizio Taglialatela
Jun 27, 2013·Proceedings of the National Academy of Sciences of the United States of America·Timothy O'LearyEve Marder
Apr 9, 2014·Proceedings of the National Academy of Sciences of the United States of America·Rahul Kumar Rathour, Rishikesh Narayanan
Jun 13, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shmuel ChenYoel Yaari
Mar 20, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Arun Anirudhan, Rishikesh Narayanan
Sep 12, 2015·Proceedings of the National Academy of Sciences of the United States of America·Guillaume DrionEve Marder
Oct 10, 2015·Cell·Henry MarkramFelix Schürmann
Jul 6, 2016·Frontiers in Pharmacology·Samuel A NeymotinWilliam W Lytton
Oct 21, 2016·Journal of Neurophysiology·Samuel A NeymotinWilliam W Lytton
Oct 12, 2017·Frontiers in Neuroanatomy·Audrey Mercer, Alex M Thomson
Feb 21, 2018·Nature Communications·Nathan W GouwensAnton Arkhipov

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Citations

May 17, 2019·PLoS Computational Biology·Elisabetta IavaroneSean L Hill
Jul 14, 2019·Hippocampus·Rahul K Rathour, Rishikesh Narayanan
Aug 31, 2019·Journal of Computational Neuroscience·Vignesh NarayananShiNung Ching
Jul 11, 2020·Neuroinformatics·Alessio Paolo Buccino, Gaute Tomas Einevoll
Dec 1, 2019·Scientific Reports·Alexander O KomendantovGiorgio A Ascoli
Jan 17, 2020·Nature Communications·Oren AmsalemIdan Segev
Oct 6, 2020·Frontiers in Computational Neuroscience·Adam MergenthalTheodore W Berger
Sep 3, 2020·International Journal of Molecular Sciences·Tatiana Anan'inaMarina Khodanovich
Jan 17, 2020·Scientific Reports·Abha Jain, Rishikesh Narayanan
Apr 24, 2020·Proceedings of the National Academy of Sciences of the United States of America·J J Johannes HjorthSten Grillner
Jun 11, 2020·Hippocampus·András EckerSrikanth Ramaswamy
May 18, 2021·Current Research in Neurobiology·Poonam Mishra, Rishikesh Narayanan
Jun 22, 2021·Frontiers in Neuroinformatics·Milagros MarínRichard R Carrillo
Jul 21, 2021·Neuroinformatics·J J Johannes HjorthAlexander Kozlov
Mar 27, 2021·Annual Review of Neuroscience·Jean-Marc Goaillard, Eve Marder
Aug 17, 2021·Neural Networks : the Official Journal of the International Neural Network Society·Ankit Roy, Rishikesh Narayanan
Nov 19, 2021·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Mohammad Amin Kamaleddin

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Methods Mentioned

BETA
fluorescence microscopy
Feature Extraction

Software Mentioned

Blue Brain Python Optimization Library (
pClamp
Neurolucida
Senselab
Electrophysiological Feature Extraction Library (
BluePyOpt

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