PMID: 11337085May 5, 2001Paper

The physiology of corticotropin-releasing hormone deficiency in mice

Peptides
L J MugliaJ A Majzoub

Abstract

A review of the generation and characterization of corticotropin-releasing hormone (CRH)-deficient mice is presented. The studies summarized demonstrate the central role of CRH in the pituitary-adrenal axis response to stress, circadian stimulation, and glucocorticoid withdrawal. Additionally, pro-inflammatory actions of CRH at sites of local inflammation are given further support. In contrast, behavioral effects during stress that had been ascribed to CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress in CRH-deficient mice strongly suggests the importance of other, possibly as yet undiscovered, CRH-like molecules.

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Citations

Apr 25, 2006·Cellular and Molecular Neurobiology·Eric M SmithThomas K Hughes
Aug 14, 2003·Trends in Pharmacological Sciences·Eric P ZorrillaGeorge F Koob
Nov 26, 2002·Trends in Genetics : TIG·Eunju SeongMargit Burmeister
Aug 21, 2003·Progress in Neurobiology·Mark J Millan
Feb 2, 2006·American Journal of Physiology. Endocrinology and Metabolism·Lauren JacobsonOwen P McGuinness
Nov 6, 2010·Reproductive Biology and Endocrinology : RB&E·Marc SimardYves Tremblay
May 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Pauline M AntonCharalabos Pothoulakis
Sep 22, 2009·Canadian Journal of Physiology and Pharmacology·Adriana AdameovaNaranjan S Dhalla
Dec 2, 2004·Brain Research. Brain Research Reviews·Katia GyslingRolando Rojas
Jun 1, 2005·Neuroscience and Biobehavioral Reviews·Alexandre UraniPeter Gass
Jul 9, 2004·Annals of the New York Academy of Sciences·L KubovcakovaR Kvetnansky
Jan 6, 2009·Annals of the New York Academy of Sciences·Richard KvetnanskýLucia Kubovcakova
Oct 14, 2004·The Journal of Allergy and Clinical Immunology·Eric S SilvermanJoseph A Majzoub
May 17, 2018·Stress : the International Journal on the Biology of Stress·Julia K GjerstadFrancesca Spiga
May 22, 2007·Stress : the International Journal on the Biology of Stress·O KrizanovaL Kubovcakova
Nov 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·Pamela EspositoTheoharis C Theoharides
Mar 8, 2007·American Journal of Physiology. Endocrinology and Metabolism·Yasumasa IwasakiKozo Hashimoto
Sep 27, 2003·Endocrinology·Anastasia KariaginaVera Chesnokova
Feb 11, 2003·Molecular Endocrinology·Ning-Ai LiuShlomo Melmed

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