The Physiology of Fear: Reconceptualizing the Role of the Central Amygdala in Fear Learning

Physiology
Orion P KeiferPaul J Marvar

Abstract

The historically understood role of the central amygdala (CeA) in fear learning is to serve as a passive output station for processing and plasticity that occurs elsewhere in the brain. However, recent research has suggested that the CeA may play a more dynamic role in fear learning. In particular, there is growing evidence that the CeA is a site of plasticity and memory formation, and that its activity is subject to tight regulation. The following review examines the evidence for these three main roles of the CeA as they relate to fear learning. The classical role of the CeA as a routing station to fear effector brain structures like the periaqueductal gray, the lateral hypothalamus, and paraventricular nucleus of the hypothalamus will be briefly reviewed, but specific emphasis is placed on recent literature suggesting that the CeA 1) has an important role in the plasticity underlying fear learning, 2) is involved in regulation of other amygdala subnuclei, and 3) is itself regulated by intra- and extra-amygdalar input. Finally, we discuss the parallels of human and mouse CeA involvement in fear disorders and fear conditioning, respectively.

References

Dec 1, 1979·Physiology & Behavior·B S KappJ R Haselton
Mar 15, 1978·The Journal of Comparative Neurology·J E Krettek, J L Price
Aug 15, 1978·Experimental Brain Research·D A Hopkins, G Holstege
Aug 1, 1978·Journal of Comparative and Physiological Psychology·T WerkaH Ursin
Jan 1, 1975·Journal of Experimental Psychology. Animal Behavior Processes·R A Rescorla, C D Heth
Jan 1, 1992·Annual Review of Neuroscience·M Davis
Nov 8, 1991·The Journal of Comparative Neurology·B H Turner, M Herkenham
Mar 8, 1989·The Journal of Comparative Neurology·M D Cassell, T S Gray
Nov 1, 1989·Journal of the Autonomic Nervous System·H A al Maskati, A W Zbrozyna
Nov 1, 1972·Journal of Comparative and Physiological Psychology·D C Blanchard, R J Blanchard
Mar 1, 1980·Pharmacology, Biochemistry, and Behavior·M GallagherP R Rapp
Sep 1, 1983·Physiology & Behavior·C D ApplegateC L McNall
Aug 1, 1983·The American Journal of Physiology·T M Galeno, M J Brody
Jul 10, 1982·The Journal of Comparative Neurology·A J McDonald
Apr 1, 1981·Pharmacology, Biochemistry, and Behavior·M GallagherJ P Pascoe
Jun 25, 1995·Journal of the Autonomic Nervous System·V G Macefield, B G Wallin
Dec 20, 1993·Behavioural Brain Research·M DavisM Kim
Dec 1, 1993·The American Journal of Physiology·R F RogersJ S Schwaber
Nov 26, 1993·Neuroscience Letters·M A MorganJ E LeDoux
Apr 15, 1993·The Journal of Comparative Neurology·N Sun, M D Cassell
Jan 1, 1993·Neuroscience·A J McDonald, J R Augustine

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Citations

Mar 26, 2016·Frontiers in Human Neuroscience·Anna Linda KrauseMartin Walter
May 26, 2016·Experimental Neurology·Rebecca C Hendrickson, Murray A Raskind
Jan 18, 2017·Cellular and Molecular Neurobiology·Sarfraj Ahmad SiddiquiAnand Prakash
Jan 27, 2018·Cerebral Cortex·Matthias F J SperlErik M Mueller
Mar 30, 2018·Nature Reviews. Neuroscience·Joseph LeDoux, Nathaniel D Daw
Dec 1, 2017·Brain Structure & Function·Olga KedoKatrin Amunts
Aug 24, 2018·Social Cognitive and Affective Neuroscience·Emily L BelleauChristine L Larson
Mar 16, 2019·Annals of the New York Academy of Sciences·Gillian A Matthews, Kay M Tye
Aug 3, 2017·Journal of Psychiatric and Mental Health Nursing·L Hollins
Aug 18, 2017·Learning & Memory·Travis D Goode, Stephen Maren
Oct 15, 2019·Frontiers in Molecular Neuroscience·Marziah HakimFatemeh Chehrehasa
Sep 17, 2016·Learning & Memory·Bianca A SilvaJohannes Gräff
Sep 2, 2017·Experimental Brain Research·Andrés Molero-Chamizo, Guadalupe Nathzidy Rivera-Urbina
May 1, 2019·Proceedings of the National Academy of Sciences of the United States of America·Donald PfaffWulf Haubensak
Nov 7, 2019·Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Österreichischer Nervenärzte und Psychiater·Patricia Pia WadowskiHenriette Löffler-Stastka
Jul 12, 2017·Cellular and Molecular Neurobiology·Romana KoprdovaAlexander Kiss
Dec 25, 2019·Scientific Reports·Hiroaki TsukanoKatsuei Shibuki
Nov 24, 2019·Molecular Psychiatry·Yiran GuRobert M Sears
Jun 28, 2018·Cell and Tissue Research·Erwin H van den Burg, Ron Stoop
Feb 2, 2019·Frontiers in Psychiatry·Adriana LoriAlicia K Smith
Feb 10, 2021·Proceedings of the National Academy of Sciences of the United States of America·Zsófia HevesiAlán Alpár
Feb 18, 2021·Learning & Memory·Thomas LapointeFrancesco Leri
Jul 8, 2021·Nature Communications·Nigel WhittleStéphane Ciocchi

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