The physiology of fetal membrane rupture: insight gained from the determination of physical properties

Placenta
R M MooreJ J Moore

Abstract

Premature rupture of the fetal membranes is a major cause of preterm birth and its associated infant morbidity and mortality. Recently, it has become clear that rupture of the fetal membranes, term or preterm, is not merely the result of the stretch and shear forces of uterine contractions, but is, in significant part, the consequence of a programmed weakening process. Work in the rat model has demonstrated that collagen remodeling, with activation of matrix metalloproteinases (MMPs), and apoptosis increase markedly in the amnion at end-gestation, suggesting that these processes are involved in fetal membrane weakening. We have developed fetal membrane strength testing equipment and a systematic tissue sampling methodology that has allowed us to demonstrate that term, non-labored, fetal membranes have a zone of weakness overlying the cervix, which contains biochemical markers of both collagen remodeling and apoptosis. These findings provide strong support for the concept of programmed fetal membrane weakening prior to labor. Our model has also been used to establish the physical properties of individual fetal membrane components (amnion, chorion), determine the sequence of events during the fetal membrane rupture process, and d...Continue Reading

Citations

Sep 14, 2012·Biomechanics and Modeling in Mechanobiology·W BuerzleE Mazza
May 8, 2010·Antioxidants & Redox Signaling·Yujing Jan HengHarry Michael Georgiou
Jan 24, 2012·Reproductive Sciences·Jerome F Strauss
Mar 12, 2009·The Journal of Clinical Endocrinology and Metabolism·C J LockwoodF Schatz
Jan 12, 2008·PloS One·Che J ConnonKeith M Meek
Jul 14, 2009·Journal of Perinatal Medicine·Mirjana A Bogavac, Snezana Brkić
Jun 2, 2011·Journal of Perinatal Medicine·Michael TchirikovHeinz Koelbl
Aug 27, 2011·Journal of Perinatal Medicine·Michael TchirikovMichael Entezami
Apr 20, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Megan L CalmusBeatrice E Lechner
Feb 12, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Erdener Ozer
Oct 22, 2013·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Ashraf F NabhanMohamed Elkadi
Aug 28, 2014·Obstetrics and Gynecology·Rebecca C PiersonDavid M Haas
Apr 23, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nevin IlhanBanu Kumbak
Jan 28, 2012·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Seung Mi LeeBo Hyun Yoon
May 21, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Marian KacerovskyCtirad Andrys
Sep 6, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroYeon Mee Kim
Mar 12, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Joon-Seok HongYeon Mee Kim
Jul 3, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Ishraq DhaifalahMarian Kacerovsky
Feb 26, 2016·Placenta·E M JoyceJ J Moore
Dec 17, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Jee Yoon ParkBo Hyun Yoon
Dec 25, 2015·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Matthew B WallensteinGary M Shaw
Nov 10, 2012·Emergency Medicine Clinics of North America·David Meguerdichian
Sep 25, 2012·Medical Engineering & Physics·Michela PerriniMartin Ehrbar
May 6, 2015·Journal of Perinatal Medicine·Roberto RomeroLami Yeo
Sep 6, 2011·Clinics in Perinatology·Christina S HanCharles J Lockwood
Aug 21, 2010·The American Journal of Pathology·Charles J LockwoodFrederick Schatz
Mar 24, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Erinn M JoyceMichael S Sacks
Mar 24, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Helen K Carnaghan, Michael R Harrison
Jan 27, 2009·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jean-Charles PasquierGeorges Mellier
Nov 12, 2015·Cornea·Mário Genilhu Bomfim PereiraLaila Christina Silveira
Apr 22, 2008·Journal de gynécologie, obstétrique et biologie de la reproduction·J-C Pasquier, M Doret

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