The Phytochemical Bergenin Enhances T Helper 1 Responses and Anti-Mycobacterial Immunity by Activating the MAP Kinase Pathway in Macrophages

Frontiers in Cellular and Infection Microbiology
Ved Prakash DwivediGobardhan Das

Abstract

Tuberculosis (TB) remains one of the greatest health concerns worldwide, which has hindered socioeconomic development in certain parts of the world for many centuries. Although current TB therapy, "Directly Observed Treatment Short-course," is effective, it is associated with unwanted side effects and the risk for the generation of drug-resistant organisms. The majority of infected individuals successfully confine the mycobacterial organisms and remain asymptotic unless immune responses are perturbed. Thus, host immunity can protect against TB and immunomodulation is therefore an attractive therapeutic option. Previous studies have shown that TNF-α and Nitric Oxide (NO) in conjunction with IFN-γ-producing T helper 1 (Th1) cells play critical roles in host protection against TB. Here, we show that bergenin, a phytochemical isolated from tender leaves ofShorea robusta, activates the MAP kinase and ERK pathways and induces TNF-α, NO and IL-12 production in infected macrophages. We further show that bergenin induces Th1 immune responses and potently inhibits bacillary growth in a murine model ofMycobacterium tuberculosisinfection. These findings identify bergenin as a potential adjunct to TB therapy.

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Citations

Oct 27, 2018·Archives of Pharmacal Research·Gil-Im MunYun-Sil Lee
Apr 13, 2019·The Journal of Biological Chemistry·Santosh KumarVed Prakash Dwivedi
Oct 20, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Qiuchen QiZhongxi Zhao
Feb 11, 2021·Immunological Reviews·Gül KilinçMariëlle C Haks
Jul 22, 2020·International Immunopharmacology·Ashima BhaskarVed Prakash Dwivedi
Jul 30, 2020·Combinatorial Chemistry & High Throughput Screening·Mradul Mohan, Debapriya Bhattacharya
Oct 16, 2021·Current Topics in Medicinal Chemistry·Reecha MadaanBairong Shen

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Methods Mentioned

BETA
FACS
lavage
PMA
flow cytometry

Software Mentioned

SPSS
SPSS10
Flow Jo

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