The phytoestrogen genistein prevents trabecular bone loss and affects thyroid follicular cells in a male rat model of osteoporosis

Journal of Anatomy
B FilipovićV Milošević

Abstract

As a major phytoestrogen of soy, genistein effectively prevents bone loss in both humans and rat models of osteoporosis. However, although the bone-sparing effects of genistein are achieved directly through estrogen receptors, its mode of action on bone by modulation of other endocrine functions is not entirely clear. Thus, thyroid hormones and calcitonin (CT) have an essential influence on bone metabolism. Besides its action on bones, in this study we examined the effect of genistein on the activity of two different endocrine cell populations, thyroid follicular and C-cells. Fifteen-month-old Wistar rats were either bilaterally orchidectomized (Orx) or sham-operated (SO). Two weeks after surgery, half of the Orx rats were treated chronically with 30 mg kg-1 b.w. genistein (Orx + G) subcutaneously (s.c.) every day for 3 weeks, while the remaining Orx rats and the SO rats were given the same volume of sterile olive oil to serve as controls. For histomorphometrical analysis of the trabecular bone microarchitecture an ImageJ public domain image processing programme was used. Thyroid sections were analysed histologically and stereologically after visualization of follicular and C-cells by immunohistochemical staining for thyroglobu...Continue Reading

References

Jan 1, 1992·Calcified Tissue International·K WatanabeK Kakudo
Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jul 1, 1994·Calcified Tissue International·J TuukkanenH K Väänänen
May 1, 1996·European Journal of Clinical Investigation·T J AllainA M McGregor
Jan 1, 1997·Brain Research Bulletin·C E RoselliJ A Resko
Feb 7, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M LuntA J Silman
Jun 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·R G ErbenM Goldberg
Oct 24, 2000·Toxicology and Applied Pharmacology·H C Chang, D R Doerge
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Ayesha SiddiqiJacky M Burrin
Feb 28, 2002·Biochemical and Biophysical Research Communications·Masako MiuraKazuwa Nakao
May 23, 2002·Recent Progress in Hormone Research·Evan R Simpson, Mitch Dowsett
Aug 15, 2003·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Vin TangprichaStuart R Chipkin
Nov 7, 2003·The Journal of Clinical Endocrinology and Metabolism·Luigi GennariRanuccio Nuti
Jul 29, 2004·Journal of Cellular Physiology·Masanori KanataniKazuo Chihara
Nov 5, 2004·Journal of Cellular Biochemistry·Wei PanZhou-Sheng Xiao
Nov 19, 2004·Calcified Tissue International·D A KhalilB H Arjmandi
Mar 5, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jeri W NievesFelicia Cosman
Jun 14, 2006·The British Journal of Nutrition·Wen-Fang Chen, Man-Sau Wong
Nov 30, 2006·Pharmacological Reviews·Karin Dahlman-WrightJan-Ake Gustafsson
Jul 5, 2007·Histochemistry and Cell Biology·Branko FilipovićMilka Sekulić
Jun 24, 2008·European Journal of Endocrinology·Andreas Mueller, Louis Gooren
Sep 6, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Joan D PenrodAlbert L Siu
Oct 28, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B FilipovićM Sekulić
May 14, 2010·Experimental Biology and Medicine·Branka Sosić-JurjevićMilka Sekulić
Aug 17, 2010·Biochemical and Biophysical Research Communications·F VargaK Klaushofer
Dec 16, 2011·Trends in Endocrinology and Metabolism : TEM·Julian A WaungGraham R Williams
Sep 8, 2012·The Journal of Endocrinology·Branka Sosic-JurjevicJosef Köhrle
Dec 19, 2013·Journal of Bioenergetics and Biomembranes·Vladimir Z AjdžanovićVerica Lj Milošević
May 6, 2014·Toxicology and Applied Pharmacology·Branka Šošić-JurjevićJosef Köhrle
Sep 10, 2014·Endocrine Reviews·Dirk VanderschuerenClaes Ohlsson

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Citations

Nov 5, 2019·Frontiers in Endocrinology·Branka Šošić-JurjevićVerica Milošević
Jun 26, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Poh-Shiow YehRuei-Ming Chen
Dec 9, 2020·Trends in Endocrinology and Metabolism : TEM·Daniele BellaviaGianluca Giavaresi
Apr 4, 2021·Animals : an Open Access Journal From MDPI·Ludmila KřížováTomáš Kašparovský
Apr 1, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Giulia Di Dalmazi, Cesidio Giuliani

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