The pigmentation of human iris influences the uptake and storing of zinc

Pigment Cell Research
Despina KokkinouUlrich Schraermeyer

Abstract

Age-related macular degeneration (AMD) is more prevalent among the elderly Caucasians than in Africans. A significant association between light iris colour, fundus pigmentation and incidence of AMD is reported, suggesting a possible correlation with melanin pigment. Zinc is known to bind to melanin in pigmented tissues and to enhance antioxidant capacity by function as a cofactor or gene expression factor of antioxidant enzymes in the eye. In this in vitro study, we investigated the uptake and storage of zinc in human irides. Irides of blue and brown human eyes were used. The number of melanocytes was measured. Tissues without any treatment served as controls. The irides were incubated with 100 microM zinc chloride in culture medium for 24 h. Specimens of the tissues were stored for the uptake examination. The remained pieces were further incubated for 3 and 7 d to investigate the storage of zinc. The concentration of zinc was measured by inductively coupled plasma mass spectrometry (ICP-MS). Melanocytes count was significantly higher in the brown tissues (P < 0.0001). Zinc concentration of blue coloured irides after 24 h zinc treatment was close to the controls. We did not observe any significant storing. In contrast, the conc...Continue Reading

References

Aug 1, 1978·The British Journal of Ophthalmology·Z Gregor, L Joffe
Dec 1, 1978·Acta Physiologica Scandinavica·B Larsson, H Tjälve
Nov 1, 1975·The Journal of Nutrition·A M Huber, S N Gershoff
May 1, 1976·Experimental Eye Research·A M Potts, P C Au
Mar 1, 1992·Current Eye Research·D A NewsomeJ G Diamond
Feb 28, 1992·Journal of Photochemistry and Photobiology. B, Biology·T Sarna
Feb 1, 1991·The American Journal of Clinical Nutrition·A S Prasad
Jan 1, 1990·Free Radical Biology & Medicine·T M Bray, W J Bettger
Jan 1, 1989·Chemico-biological Interactions·J Borovanský, P A Riley
Feb 1, 1988·Archives of Ophthalmology·D A NewsomeE Miller
Feb 15, 1985·American Journal of Ophthalmology·J J WeiterK A Fitch
Jan 1, 1983·European Journal of Cancer & Clinical Oncology·J Borovanský, P A Riley
Sep 1, 1982·Survey of Ophthalmology·Z A Karcioglu
Aug 1, 1983·American Journal of Epidemiology·L G HymanS L Fine
May 1, 1981·Experimental Eye Research·B J Panessa, J A Zadunaisky
Jan 15, 1994·American Journal of Ophthalmology·F G HolzR A Weale
Jan 1, 1993·Experimental Eye Research·D A SamuelsonN C Leone
Apr 1, 1996·Archives of Ophthalmology·P D ImeschI H Wallow
Jun 1, 1996·Zeitschrift für Ernährungswissenschaft·G RimbachK Krämer
Jan 20, 1999·The British Journal of Ophthalmology·G ChaineH Bourgeois
May 16, 2002·Current Opinion in Ophthalmology·Leslie Hyman, Rebecca Neborsky
Dec 4, 2003·Clinical & Experimental Ophthalmology·Caroline M NicolasCatherine A McCarty

❮ Previous
Next ❯

Citations

May 21, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Despina KokkinouUlrich Schraermeyer
Nov 11, 2005·Pigment Cell Research·Albert R Wielgus, Tadeusz Sarna
May 11, 2007·Veterinary Pathology·M K ZarfossR R Dubielzig
Jan 15, 2014·Metallomics : Integrated Biometal Science·Héctor Gonzalez-IglesiasMiguel Coca-Prados
May 31, 2019·Molecular Nutrition & Food Research·Rosie GilbertEszter Emri
Feb 14, 2012·Metallomics : Integrated Biometal Science·Antje BiesemeierOliver Eibl

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Despina KokkinouUlrich Schraermeyer
Chemico-biological Interactions
J Borovanský, P A Riley
© 2021 Meta ULC. All rights reserved