PMID: 37417Feb 1, 1979

The pineal gland as an APUD organ: supporting evidence and implications

Medical Hypotheses
A S Leong, C D Matthews

Abstract

It is only in recent years that the pineal gland has emerged from being thought of as non-functional and unimportant. The rise from obscurity has been the result of the interest of investigators of multidisplinary origins; such approaches, whilst clearly advancing understanding, also tend to leave knowledge fragmentary. In the last decade, a new neuroendocrine axis known as the APUD system has been delineated and scientifically accepted. The essence of the concept has been to link a physically widely dispersed and apparently unconnected series of glandular structures by a common embryological derivation and their secretion of closely similar functional products. The present proposal collates evidence for the inclusion of the pineal gland within the APUD system. In addition, because of the proven connections and response of the pineal gland to environmental changes, it is hypothesised that pineal products may provide the link between the environment and other members of the widely dispersed APUD system and thereby temper body homeostasis.

References

Nov 1, 1990·Biulleten' eksperimental'noĭ biologii i meditsiny·V M Rozum
Jan 1, 1986·Neuroscience and Biobehavioral Reviews·P B FoleyA Foldes
Jan 30, 2008·Neurobiology of Disease·Robert Y MooreDavid J Brooks
Aug 14, 2003·Brain Research·Robert Y MooreDavid J Brooks
Jan 1, 1987·Journal of Pineal Research·P B Foley, K D Cairncross
Jan 1, 1990·The International Journal of Neuroscience·R Sandyk

Citations

Sep 22, 1975·Zeitschrift Für Krebsforschung Und Klinische Onkologie. Cancer Research and Clinical Oncology·A G Pearse
May 1, 1977·Journal of Steroid Biochemistry·D J KennawayM Schilthuis
Aug 1, 1975·The American Journal of Anatomy·A Lukaszyk, R J Reiter
May 22, 1975·Nature·N T RaikhlinV N Tolkachev
Feb 1, 1975·The Journal of Clinical Endocrinology and Metabolism·J ArendtP C Sizonenko
Jun 1, 1969·Endocrinology·D C Klein, S V Lines

Related Concepts

Neuroendocrine Tumors
Melatonin
Neurosecretory Systems
Dicom Derivation
Process of Secretion
Neurosecretion
Malignant Neoplasm of Pineal Gland
Cell Secretion
Gland
APUD Cells

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