PMID: 6169801Jan 1, 1981Paper

The pineal gland of the mole (Talpa europaea L.). VII. Activity of hydroxyindole-O-methyltransferase (HIOMT) in the formation of 5-methoxytryptophan, 5-methoxytryptamine, 5-methoxyindole-3-acetic acid, 5-methoxytryptophol and melantonin in the eyes and the pineal gland

Journal of Neural Transmission
P PévetG F de Reuver

Abstract

Using a method in which no substrate is added to the incubation medium, the capacity of HIOMT to synthesize 5-methoxytryptophan, 5-methoxytryptamine, 5-methoxyindole-3-acetic acid, 5-methoxytryptophol and melatonin has been determined in the pineal and the eyes of the mole, a mammal having an atrophied visual system. The results demonstrate that the indoleamine metabolism in the retina is similar to the indoleamine metabolism in the pineal. Moreover, in all animals studied both eyes together synthesize 2 to 30 times more of 5-methoxyindoles than the pineal, a result which proves again that the pineal is not the only and not always the most important source of 5-methoxyindoles. With the exception of 5-methoxyindole-3-acetic acid, the synthesis of which is practically neglectable, the production of all other 5-methoxyindoles in the pineal as well as in the retinae is always larger than that of melatonin. In the pineal, 5-methoxytryptophan, for example, is synthesized in a quantity which is 60 to 170 times larger than that of melatonin, while in the retinae the synthesized amount of 5-methoxytryptophan is even 60 to 1000 times larger than that of melatonin.

References

Jan 1, 1977·Neuroendocrinology·B Benson
Nov 1, 1976·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G A BubenikL J Grota
Jan 1, 1979·Progress in Brain Research·M G Balemans
Jul 15, 1977·Life Sciences·R J Reiter, M K Vaughan
Apr 13, 1979·Science·W A Gern, C L Ralph
Oct 1, 1979·The Journal of Endocrinology·S J CarterD L Larson-Carter
Jan 1, 1979·Psychoneuroendocrinology·P E MullenC Linsell
Aug 1, 1976·Endocrinology·Y Ozaki, H J Lynch
Oct 1, 1976·Journal of Ultrastructure Research·P Pevet, J P Collin
May 1, 1991·Cell and Tissue Research·B PrzybylskaP Pévet
May 1, 1969·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·A G Pearse
Feb 16, 1972·Biochemical and Biophysical Research Communications·R W PelhamI M Campbell
Apr 1, 1974·General and Comparative Endocrinology·S F PangD P Reilly
Dec 1, 1970·The Journal of Endocrinology·A G GonaW Etkin
Mar 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·W R HollowayG M Brown
Jan 1, 1980·Journal of Neural Transmission·M G BalemansJ Van Benthem

❮ Previous
Next ❯

Citations

Jul 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·A M Galzin, S Z Langer
Jan 1, 1982·Journal of Neural Transmission·P Pévet, C Haldar-Misra
Jan 1, 1983·Psychoneuroendocrinology·P Pévet
Jan 1, 1996·Neurochemistry International·M MøllerB Cozzi
Sep 1, 1985·Journal of Neurosurgery·S S Erlich, M L Apuzzo
Dec 29, 1989·Biochemical and Biophysical Research Communications·C W TsangS F Pang
Nov 22, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Rüdiger Hardeland
Jul 1, 2013·Expert Review of Endocrinology & Metabolism·Mounir OuzirNouria Lakhdar-Ghazal
Jan 1, 1985·Analytical Biochemistry·S Higa, S P Markey

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.