The pinwheel experiment revisited

Journal of Theoretical Biology
B J Roth

Abstract

The critical point hypothesis explains the origin of some cardiac arrhythmias, and the bidomain model describes electrical stimulation of the heart. In this paper, the critical point hypothesis is combined with the bidomain model. The result is four new predictions about the pinwheel experiment, a fundamental experiment in cardiac electrophysiology. These are: (1) The duration of the vulnerable period during cathodal S2 stimulation is longer for an S1 wavefront propagating perpendicular to the fibers than for an S1 wavefront propagating parallel to the fibers. (2) For anodal S2 stimulation with the S1 wavefront propagating parallel to the fibers, the vulnerable period splits into two periods with an "invulnerable period" between them. (3) For anodal S2 stimulation with the S1 wavefront propagating perpendicular to the fibers, the vulnerable period consists of only one period. (4) A previously suggested mechanism for the upper limit of vulnerability (S2 is so strong that the entire tissue is depolarized by an amount greater than S*) is no longer applicable.

Citations

Apr 5, 2000·Journal of Cardiovascular Electrophysiology·A E LindblomN A Trayanova
Mar 19, 2004·Journal of Cardiovascular Electrophysiology·Shien-Fong Lin
Sep 15, 2004·Journal of Theoretical Biology·Bradley J Roth
Jan 29, 2002·Journal of Theoretical Biology·Alexandre Sambelashvili, Igor R Efimov
Oct 17, 2002·Journal of Biosciences·A T Winfree
Nov 30, 1999·Circulation Research·I BanvilleW M Smith
Feb 24, 2001·Canadian Journal of Physiology and Pharmacology·Y YamanouchiI R Efimov
May 21, 2019·Frontiers in Physiology·Maximilian FunkenTobias Bruegmann
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ming-Jim YangZhilin Qu
Nov 24, 1999·The American Journal of Physiology·S F IdrissR E Ideker
Oct 24, 1998·Progress in Biophysics and Molecular Biology·A T Winfree

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Electrophysiology

Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Cardiac Conduction System

The cardiac conduction system is a specialized tract of myocardial cells responsible for maintaining normal cardiac rhythm. Discover the latest research on the cardiac conduction system here.

Related Papers

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Philippe ComtoisStanley Nattel
Journal of Theoretical Biology
Alexandre Sambelashvili, Igor R Efimov
Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
Hervé Henry, Wouter-Jan Rappel
Physical Review Letters
Jeffrey J FoxEberhard Bodenschatz
© 2022 Meta ULC. All rights reserved