Abstract
The critical point hypothesis explains the origin of some cardiac arrhythmias, and the bidomain model describes electrical stimulation of the heart. In this paper, the critical point hypothesis is combined with the bidomain model. The result is four new predictions about the pinwheel experiment, a fundamental experiment in cardiac electrophysiology. These are: (1) The duration of the vulnerable period during cathodal S2 stimulation is longer for an S1 wavefront propagating perpendicular to the fibers than for an S1 wavefront propagating parallel to the fibers. (2) For anodal S2 stimulation with the S1 wavefront propagating parallel to the fibers, the vulnerable period splits into two periods with an "invulnerable period" between them. (3) For anodal S2 stimulation with the S1 wavefront propagating perpendicular to the fibers, the vulnerable period consists of only one period. (4) A previously suggested mechanism for the upper limit of vulnerability (S2 is so strong that the entire tissue is depolarized by an amount greater than S*) is no longer applicable.
Citations
Apr 5, 2000·Journal of Cardiovascular Electrophysiology·A E LindblomN A Trayanova
Jun 16, 2007·The Journal of Physiology·Veniamin Y SidorovFranz Baudenbacher
Mar 19, 2004·Journal of Cardiovascular Electrophysiology·Shien-Fong Lin
Sep 15, 2004·Journal of Theoretical Biology·Bradley J Roth
May 9, 2006·Biophysical Journal·Zhilin QuJames N Weiss
May 9, 2006·Biophysical Journal·Zhilin QuJames N Weiss
Jan 29, 2002·Journal of Theoretical Biology·Alexandre Sambelashvili, Igor R Efimov
Oct 17, 2002·Journal of Biosciences·A T Winfree
Nov 30, 1999·Circulation Research·I BanvilleW M Smith
Feb 24, 2001·Canadian Journal of Physiology and Pharmacology·Y YamanouchiI R Efimov
Dec 25, 2016·American Journal of Physiology. Heart and Circulatory Physiology·S RossiE Macchi
May 21, 2019·Frontiers in Physiology·Maximilian FunkenTobias Bruegmann
Jun 26, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Ming-Jim YangZhilin Qu
Nov 24, 1999·The American Journal of Physiology·S F IdrissR E Ideker
Oct 24, 1998·Progress in Biophysics and Molecular Biology·A T Winfree