PMID: 9552375Jan 1, 1995Paper

The PITSLRE protein kinase family

Progress in Cell Cycle Research
J M LahtiV J Kidd

Abstract

A family of p34Cdc2 related protein kinases, the PITSLRE kinases, is generated by alternative splicing and promoter utilization from three duplicated and tandemly linked genes on human chromosome 1p36.3, which is frequently deleted during the late stages of tumorigenesis. PITSLRE mRNA, protein, and enzyme activity are induced during Fas receptor- and glucocorticoid-mediated apoptosis of human T cells. Several PITSLRE isoforms are specific targets of proteolysis during apoptosis, generating an enzymatically active 50 kDa isoform. Inhibition of this protease activity blocks PITSLRE processing and enzyme activation, as well as apoptosis. Thus, PITSLRE kinases may be integral downstream components of apoptotic signal transduction pathway(s). Furthermore, PITSLRE genes, and their products, are physically altered in human neuroblastoma tumors, suggesting that they may be tumor suppressors.

Citations

Jul 13, 2000·Cell Death and Differentiation·P J Utz, P Anderson
May 23, 2003·Oncogene·Heinrich KovarHelmut Gadner
Jul 25, 2009·Molecular Biology of the Cell·Meike BoosenUte Preuss
Jul 17, 2009·Critical Reviews in Biochemistry and Molecular Biology·Katrien Van Der KelenLieven De Veylder
Feb 27, 2001·Current Opinion in Oncology·S Halachmi, B A Gilchrest
Nov 20, 1998·Molecular Biotechnology·M R FowlerM C Elliott
Dec 23, 2011·Clinical and Experimental Dermatology·G ZhangP Yao
Sep 14, 2000·Proceedings of the National Academy of Sciences of the United States of America·J M AngelastroL A Greene
Jun 5, 2003·Mechanisms of Development·Anne RascleDavid S Hogness
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