PMID: 9185671May 23, 1997Paper

The pituitary adenylate cyclase-activating polypeptide-induced phosphorylation of the transcription factor CREB (cAMP response element binding protein) in the rat suprachiasmatic nucleus is inhibited by melatonin

Neuroscience Letters
M KoppH W Korf

Abstract

The mammalian hypothalamic suprachiasmatic nucleus (SCN) is an endogenous pacemaker generating circadian rhythms. SCN activity is synchronized with environmental light/dark cycles by photic information primarily transmitted via the retinohypothalamic tract (RHT). The SCN controls synthesis and release of melatonin, the hormone of the pineal gland. Melatonin itself feeds back to the SCN. Using brain slice technique and immunocytochemistry we demonstrate that (1) pituitary adenylate cyclase-activating polypeptide (PACAP) induces the phosphorylation of the transcription factor cAMP response element binding protein (CREB) in the SCN during late subjective day and (2) melatonin inhibits this PACAP-induced phosphorylation. Our data suggest that PACAP is a neurotransmitter which affects gene expression in the SCN probably via the cAMP signaling pathway and that the antagonistic effect of melatonin mirrors a feed-back loop within the circadian system.

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Citations

Jul 23, 1999·Brain Research·J M LeeM E Harrington
Dec 4, 2003·General and Comparative Endocrinology·Valér CsernusAkira Arimura
Nov 1, 2002·Regulatory Peptides·Anikó Somogyvári-VighAkira Arimura
Nov 24, 2012·Nutrition Research Reviews·Cathríona Rosemary Loonam, Anne Mullen
Feb 6, 2010·Proceedings of the National Academy of Sciences of the United States of America·R Anne StetlerJun Chen
May 20, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Dorothea RatElzbieta Kojro
Jan 17, 2003·Molecular and Cellular Biology·Xiaowei JinDavid R Weaver
Apr 29, 2006·Molecular and Cellular Endocrinology·H W Korf, C von Gall
Dec 20, 2002·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Lutz Vollrath
Jan 13, 2015·Molecular and Cellular Endocrinology·Yi Pan, Lennard P Niles
Apr 29, 1998·Journal of Biological Rhythms·T Roenneberg, M Merrow
Oct 5, 2017·British Journal of Pharmacology·Tahlia Sundrum, Christopher S Walker
Jul 14, 2019·Cephalalgia : an International Journal of Headache·Hashmat GhanizadaMessoud Ashina
Aug 15, 2003·Chronobiology International·H W KorfJ Stehle
Mar 8, 2003·Journal of Neuroendocrinology·J H StehleH-W Korf

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