PMID: 9416768Jan 1, 1997Paper

The pituitary folliculo-stellate cell line TtT/GF augments basal and TRH-induced prolactin secretion by GH3 cell

Life Sciences
K KoikeM Inoue

Abstract

Numerous functions have been ascribed to anterior pituitary folliculo-stellate (FS) cells. Recently, we established a pituitary FS-like cell line (TtT/GF) from an isologously transplantable pituitary thyrotropic tumor. Here we investigated the effect of FS cells on prolactin (PRL) secretion by using a co-culture system between TtT/GF cells and GH3 cells. We observed that co-culture with TtT/GF cells significantly increased basal PRL secretion without affecting the growth rate of GH3 cells. Further, addition of anti-cytokine-induced neutrophil chemoattractant (CINC) antibody partially reduced PRL secretion in co-culture of GH3 cells with 10% TtT/GF cells. Co-culture with 5% TtT/GF cells also markedly enhanced the PRL response to thyrotropin-releasing hormone (TRH) by GH3 cells, while addition of anti-CINC antibody had no effects on the enhanced PRL response to TRH. These results suggest that FS cells augment basal PRL secretion and enhance the secretory response of PRL to TRH by a paracrine mechanism.

References

Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·N FerraraD Gospodarowicz
Jul 1, 1989·Endocrinology·B L SpangeloR M MacLeod
Nov 30, 1989·Biochemical and Biophysical Research Communications·D Gospodarowicz, K Lau
Mar 1, 1953·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·J F RINEHART, M G FARQUHAR

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Citations

Jul 5, 2005·European Journal of Endocrinology·Wilfried Allaerts, Hugo Vankelecom
Nov 16, 2004·Molecular and Cellular Endocrinology·Guck T OoiRuth M Escalona

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