The pivotal role of sampling recurrent tumors in the precision care of patients with tumors of the central nervous system

Cold Spring Harbor Molecular Case Studies
Derek WongStephen Yip

Abstract

Effective management of brain and spine tumors relies on a multidisciplinary approach encompassing surgery, radiation, and systemic therapy. In the era of personalized oncology, the latter is complemented by various molecularly targeting agents. Precise identification of cellular targets for these drugs requires comprehensive profiling of the cancer genome coupled with an efficient analytic pipeline, leading to an informed decision on drug selection, prognosis, and confirmation of the original pathological diagnosis. Acquisition of optimal tumor tissue for such analysis is paramount and often presents logistical challenges in neurosurgery. Here, we describe the experience and results of the Personalized OncoGenomics (POG) program with a focus on tumors of the central nervous system (CNS). Patients with recurrent CNS tumors were consented and enrolled into the POG program prior to accrual of tumor and matched blood followed by whole-genome and transcriptome sequencing and processing through the POG bioinformatic pipeline. Sixteen patients were enrolled into POG. In each case, POG analyses identified genomic drivers including novel oncogenic fusions, aberrant pathways, and putative therapeutic targets. POG has highlighted that pe...Continue Reading

References

Jul 24, 2001·Neuro-oncology·R J JacksonR Sawaya
Oct 1, 2003·Pathology International·Hirokazu AwayaKouki Inai
Sep 15, 2004·Acta neurochirurgica·N FakhraiC Marosi
Mar 11, 2005·The New England Journal of Medicine·Monika E HegiRoger Stupp
Nov 18, 2006·Lancet Neurology·Markus J RiemenschneiderGuido Reifenberger
Jul 10, 2007·Acta Neuropathologica·David N LouisPaul Kleihues
Aug 5, 2008·Neuro-oncology·Wolfgang WickUNKNOWN European Organisation for Research and Treatment of Cancer and the National Cancer Institute of Canada Clinical Trials Group
Sep 6, 2008·Science·D Williams ParsonsKenneth W Kinzler
Mar 11, 2009·The Lancet Oncology·Thomas E MerchantRobert A Sanford
Jul 9, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Stephen YipDavid N Louis
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
Aug 6, 2011·Science·Chetan BettegowdaKenneth W Kinzler
Feb 4, 2012·The Lancet Oncology·Brian P WalcottManuel J Ferreira
Apr 25, 2012·Journal of Cell Science·Gerardo JiménezZe'ev Paroush
Oct 16, 2012·Journal of Neurosurgery·Bernt Filip HasseleidEirik Helseth
Nov 13, 2012·Nucleic Acids Research·Atanas KamburovRalf Herwig
Jan 19, 2013·Medical Oncology·Monica CantileGerardo Botti
Jan 22, 2013·Nature Genetics·Priscilla K BrastianosRameen Beroukhim
Feb 16, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrea SottorivaSimon Tavaré
Mar 1, 2013·The New England Journal of Medicine·Samuel Aparicio, Carlos Caldas
Oct 15, 2013·Cell·Cameron W BrennanUNKNOWN TCGA Research Network
Feb 21, 2014·Nature·Matthew ParkerRichard J Gilbertson
Jun 14, 2014·Science·Anoop P PatelBradley E Bernstein
Aug 13, 2014·Proceedings of the National Academy of Sciences of the United States of America·Brian J GillPeter Canoll
Sep 11, 2014·Nature Communications·Nicolas StranskyChristoph Lengauer
Mar 4, 2015·Annals of Oncology : Official Journal of the European Society for Medical Oncology·F FaveroC Swanton
Apr 8, 2015·Nature Genetics·Hiromichi SuzukiSeishi Ogawa
May 7, 2015·Acta Neuropathologica·Kenneth AldapeAndreas von Deimling
May 29, 2015·Annals of Neurology·Vincent GleizeMarc Sanson
Jun 10, 2015·The Journal of Experimental Medicine·Soung-Hoon LeeKang-Yell Choi
Jun 11, 2015·The New England Journal of Medicine·UNKNOWN Cancer Genome Atlas Research NetworkJianan Zhang
Jun 11, 2015·The New England Journal of Medicine·Jeanette E Eckel-PassowRobert B Jenkins
Jul 19, 2015·Neuro-oncology·Matthew S WaitkusHai Yan
Jul 22, 2015·Cancer Discovery·Mel Greaves
Sep 12, 2015·Genes, Chromosomes & Cancer·Vijay PadulNeelam Vishwanath Shirsat
Mar 26, 2016·Neurosurgery Clinics of North America·Wenya Linda BiIan F Dunn
Mar 30, 2016·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M R JonesH J Lim

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Datasets Mentioned

BETA
E-MTAB-513
EGAS00001001159

Methods Mentioned

BETA
biopsy
biopsies
surgical resections
PCR
RNA-seq

Clinical Trials Mentioned

NCT02155621

Software Mentioned

WGTA
ConsensusPathDB
POG
DGIdb

Related Concepts

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Cancer Genomics (Keystone)

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