The place of sulfonylureas in the therapy for type 2 diabetes mellitus

Metabolism: Clinical and Experimental
Stefano Del Prato, Nicolò Pulizzi

Abstract

Sulfonylureas are still largely used for treatment of type 2 diabetic patients, and they still occupy a central position in many international therapy guidelines. More recently concern has been raised with respect to possible adverse effects associated with the use of these agents. Sulfonylureas are, indeed, believed to favor the development of hypoglycemia, to accelerate beta cell apoptosis and beta-cell exhaustion, and to impair endothelial function with increased risk for ischemic complications. However, because of the intrinsic pathogenetic heterogeneity of type 2 diabetes, sulfonylureas are likely to remain a therapeutic option. Careful choice of a specific sulfonylurea should be made on the basis of efficacy, safety, convenience, tissue specificity, and neutrality with respect to the beta cell. In this review the advantage:disadvantage ratio of available sulfonylureas is analyzed with the purpose of providing a critical clinical appraisal of the role of sulfonylureas in the modern treatment of type 2 diabetes.

References

Apr 2, 1988·British Medical Journal·R E Ferner, H A Neil
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert
Aug 1, 1995·Diabetes Research and Clinical Practice·R C Turner, R R Holman
Jul 1, 1996·Journal of the American Geriatrics Society·R I ShorrM R Griffin
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K E DraegerR Rosskamp
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·M Lazdunski
Sep 1, 1996·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·K GeisenJ G Papp
Dec 24, 1997·Diabetes Care·T P GilmerW A Rush
Feb 16, 1999·Archives of Internal Medicine·H Ben-AmiY Edoute
Oct 8, 1999·Diabetic Medicine : a Journal of the British Diabetic Association
Sep 27, 2000·Journal of Diabetes and Its Complications·R C O'BrienJ Mercuri
Jan 30, 2002·Diabetes·Stefano Del PratoRiccardo C Bonadonna
Jul 24, 2002·Diabetologia·B Jönsson, UNKNOWN CODE-2 Advisory Board
Jul 24, 2002·Diabetologia·A LieblUNKNOWN ODE-2 Advisory Board
Feb 8, 2003·The Journal of Clinical Endocrinology and Metabolism·Tsung-Ming Lee, Tsai-Fwu Chou
Mar 26, 2003·QJM : Monthly Journal of the Association of Physicians·A Bagust, S Beale
Aug 27, 2003·Metabolism: Clinical and Experimental·Geneviève RenierOmar Serri
Dec 11, 2003·Diabetologia·A GastaldelliUNKNOWN San Antonio metabolism study
Dec 25, 2003·Diabetes Care·UNKNOWN American Diabetes Association
May 27, 2004·Cardiovascular Drugs and Therapy·Helen L MaddockDerek M Yellon
Aug 13, 2004·European Journal of Clinical Investigation·G SchernthanerK M Shaw
Aug 17, 2004·The Medical Clinics of North America·Ralph A DeFronzo
Oct 27, 2004·Diabetes Care·John B BuseUNKNOWN Exenatide-113 Clinical Study Group
Jan 12, 2005·Journal of Diabetes and Its Complications·Silvia Del GuerraPiero Marchetti
Jan 19, 2005·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·B Ahrén, O Schmitz

❮ Previous
Next ❯

Citations

Sep 7, 2012·Diabetes, Obesity & Metabolism·G Drews, M Düfer
Jun 28, 2007·International Journal of Clinical Practice. Supplement·Brunetti P
Jun 28, 2007·International Journal of Clinical Practice. Supplement·M Hanefeld
Jun 28, 2007·International Journal of Clinical Practice. Supplement·G Derosa
Sep 29, 2011·International Journal of Clinical Practice·S Al SifriUNKNOWN 2010 Ramadan Study Group
Jun 2, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Mohamed A Almaatouq
Mar 22, 2007·Expert Opinion on Therapeutic Targets·Andrea Brambilla, Paola Tarroni
Mar 13, 2010·Expert Review of Cardiovascular Therapy·Christina L Aquilante
Sep 21, 2013·Expert Opinion on Drug Discovery·Maliheh SafaviMohammad Abdollahi
Dec 26, 2007·Current Medical Research and Opinion·S M BeardR A Malik
Aug 27, 2011·Current Medical Research and Opinion·Scott E Nelson
Dec 25, 2007·Current Medical Research and Opinion·Andrew J Krentz
Apr 22, 2011·Current Medical Research and Opinion·S R AravindUNKNOWN 2009 Ramadan Study Group
Jun 12, 2010·Diabetes Research and Clinical Practice·Masatoshi KikuchiMatthew Goodman
Jan 21, 2016·Journal of Diabetes Research·Kim E Innes, Terry Kit Selfe
Jul 18, 2008·Transplantation Reviews·Roslyn B Mannon
Feb 20, 2007·The American Journal of Cardiology·Frederick A Masoudi, Silvio E Inzucchi
Jan 25, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·S A AmielK Jameson
Mar 20, 2016·International Journal of Biological Macromolecules·Dun JinXiang-Yang Wu
Dec 20, 2012·Journal of Diabetes Investigation·Akira KubotaIkuro Matsuba
May 3, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Mads HornumBo Feldt-Rasmussen
Jun 13, 2015·European Heart Journal·Ele Ferrannini, Ralph A DeFronzo
Apr 5, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Wei-Chih KanJiunn-Jye Chuu
Dec 3, 2014·The Medical Clinics of North America·Stephen A Brietzke
Dec 25, 2013·Clinical & Developmental Immunology·Gabriela Hurtado-AlvaradoBeatriz Gómez-González
Dec 22, 2011·Journal of Pharmacological Sciences·Ju-Young KimByung-Joon Kim
Jul 23, 2016·Pain Research & Management : the Journal of the Canadian Pain Society = Journal De La Société Canadienne Pour Le Traitement De La Douleur·Kimberly T SibilleChristopher S Nielsen
May 22, 2013·Journal of Environmental and Public Health·Farahnaz KhajehnasiriHassan Hashemi
Nov 4, 2016·Nature Reviews. Drug Discovery·Amy K RinesPere Puigserver
Jan 18, 2017·Palliative & Supportive Care·Kirstin F MaltbyJane L Phillips
Jun 4, 2010·Arquivos brasileiros de endocrinologia e metabologia·Lucio VilarAmaro Gusmão

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis