The placental component and neonatal outcome in singleton vs. twin pregnancies complicated by gestational diabetes mellitus

Placenta
Eran WeinerMichal Kovo

Abstract

We aimed to compare placental histopathological lesions and neonatal outcome in singleton vs. twin pregnancies complicated by gestational diabetes mellitus (GDM). Maternal characteristics, neonatal outcomes, and placental histopathology reports of pregnancies complicated by GDM, between 1/2008-10/2016, were reviewed. Results were compared between singletons (singleton group) and dichorionic-diamniotic twins (twin group). Placental lesions were classified as placental weight abnormalities, maternal and fetal vascular malperfusion lesions (MVM, FVM), inflammatory lesions, and lesions associated with chronic villitis. LGA was defined as birth-weight ≥90th percentile. Composite adverse neonatal outcome was defined as one or more early neonatal complications. Compared with the twin group (n = 57), the singleton group (n = 228) was characterized by higher gestational-age (38.6 ± 0.9 vs. 35.1 ± 1.8 weeks, p < 0.001) and a higher rate of insulin treatment (32.9% vs. 17.5%, p = 0.023). Placentas from the singleton group were characterized by higher rates of MVM lesions (54.4% vs. 30.7%, p < 0.001), villitis of unknown etiology (VUE, 5.7% vs. 0.9%, p = 0.040), villous immaturity (10.1% vs. 0.9%, p = 0.001), and placental weight <10th per...Continue Reading

Citations

Jul 30, 2019·American Journal of Reproductive Immunology : AJRI·Ashley V HillBrandie D Taylor
Nov 6, 2018·Endocrine, Metabolic & Immune Disorders Drug Targets·Julia Rodríguez-CastelánEstela Cuevas-Romero
May 26, 2018·Archivum Immunologiae Et Therapiae Experimentalis·Łukasz SzylbergAndrzej Marszałek
Dec 21, 2018·Archives of Gynecology and Obstetrics·Ron MaymonHoward Cuckle
Aug 20, 2019·Archives of Gynecology and Obstetrics·Yossi MizrachiMichal Kovo
Sep 24, 2020·The Journal of International Medical Research·Kamil Konrad HozyaszKatarzyna Chyż
Mar 20, 2020·Journal of Assisted Reproduction and Genetics·Yossi MizrachiMichal Kovo
Mar 17, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Ilia KleinerEran Weiner

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