The placental problem: linking abnormal cytotrophoblast differentiation to the maternal symptoms of preeclampsia

Reproductive Biology and Endocrinology : RB&E
S J Fisher

Abstract

The placenta is a remarkable organ. In normal pregnancy its specialized cells (termed cytotrophoblasts) differentiate into various specialized subpopulations that play pivotal roles in governing fetal growth and development. One cytotrophoblast subset acquires tumor-like properties that allow the cells to invade the decidua and myometrium, a process that attaches the placenta to the uterus. The same subset also adopts a vascular phenotype that allows these fetal cells to breach and subsequently line uterine blood vessels, a process that channels maternal blood to the rest of the placenta. In the pregnancy complication preeclampsia, which is characterized by the sudden onset of maternal hypertension, proteinuria and edema, cytotrophoblast invasion is shallow and vascular transformation incomplete. These findings, together with very recent evidence from animal models, suggest that preeclampsia is associated with abnormal placental production of vasculogenic/angiogenic substances that reach the maternal circulation with the potential to produce at least a subset of the clinical signs of this syndrome. The current challenge is to build on this knowledge to design clinically useful tests for predicting, diagnosing and treating this ...Continue Reading

References

Nov 1, 1989·American Journal of Obstetrics and Gynecology·J M RobertsM K McLaughlin
Oct 1, 1996·American Journal of Obstetrics and Gynecology·D S Dizon-TownsonK Ward
Feb 1, 1997·British Journal of Obstetrics and Gynaecology·A P CockellL Poston
Jul 1, 1998·British Journal of Obstetrics and Gynaecology·M KnightI L Sargent
Nov 10, 2000·Lancet·J J Walker
Jan 5, 2002·The New England Journal of Medicine·Rolv SkjaervenRolv T Lie
Mar 8, 2003·Hypertension·James M RobertsUNKNOWN NHLBI Working Group on Research on Hypertension During Pregnancy
Jun 11, 2003·American Journal of Epidemiology·Audrey F SaftlasBaha M Sibai
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·James M RobertsUNKNOWN National Heart Lung and Blood Institute
Aug 12, 2003·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Peter von DadelszenJames M Roberts
Feb 7, 2004·The Journal of Clinical Endocrinology and Metabolism·Ravi ThadhaniS Ananth Karumanchi
Feb 7, 2004·The New England Journal of Medicine·Richard J LevineS Ananth Karumanchi
May 7, 2004·The New England Journal of Medicine·Vassilis TsatsarisJean Michel Foidart
Apr 4, 2009·Journal of Spinal Disorders & Techniques·Luc DuongHubert Labelle

❮ Previous
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Citations

Sep 8, 2006·The New England Journal of Medicine·Richard J LevineUNKNOWN CPEP Study Group
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Vicki PlaksZena Werb
Oct 20, 2004·The Journal of Experimental Medicine·Peter Parham
Jul 6, 2007·Stem Cells and Development·Isabelle PeifferJacques A Hatzfeld
Oct 21, 2010·Human Reproduction Update·Ewka C M NelissenJohannes L H Evers
Apr 24, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mohammad N UddinJules B Puschett
Oct 20, 2005·Reproductive Biology and Endocrinology : RB&E·Luana PaulesuFelice Petraglia
Aug 1, 2009·Clinical Chemistry and Laboratory Medicine : CCLM·Yali HuYayi Hou
Nov 30, 2011·Epigenomics·Boris Novakovic, Richard Saffery
Dec 23, 2014·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·P HeG Zhang
Sep 22, 2015·Hypertension in Pregnancy : Official Journal of the International Society for the Study of Hypertension in Pregnancy·Xinwei ShiYuanyuan Wu
Jul 23, 2014·International Journal of Environmental Research and Public Health·Darijana HorvatMohammad Nasir Uddin
Oct 15, 2010·Kidney International·Xiaoping QingJane E Salmon
Nov 1, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Markus SchmidtSabine Kasimir-Bauer
Apr 17, 2008·The Journal of Obstetrics and Gynaecology Research·Craig A H RichardJulie A DeLoia
Oct 18, 2014·Archives of Gynecology and Obstetrics·Vanessa Resende Souza SilvaMarly Aparecida Spadotto Balarin
Jun 4, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Beenish RahatJyotdeep Kaur
Aug 26, 2016·Hematology·César Homero Gutierrez-AguirreDavid Gómez-Almaguer
Mar 11, 2017·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Yan-Ting XuRui Zhu
Mar 10, 2017·American Journal of Reproductive Immunology : AJRI·Shilpi SehgalS K Pallavi
Sep 14, 2007·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Juan Pedro KusanovicJimmy Espinoza
Aug 26, 2006·Developmental Biology·Akraporn PrakobpholSusan J Fisher
May 11, 2007·Journal of Reproductive Immunology·Hernan D Kopcow, S Ananth Karumanchi
Dec 13, 2016·Medicina·Viktorija TarasevičienėRegina Mačiulevičienė
May 9, 2013·Reproductive Sciences·Daniel M KrausChad A Grotegut
Jan 18, 2013·Biotechnology Journal·Karthik TiruthaniBalaji Rao
Dec 21, 2013·Reproduction : the Official Journal of the Society for the Study of Fertility·Carly CumanEvdokia Dimitriadis
Jan 13, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nikolina DochevaOffer Erez

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Methods Mentioned

BETA
biopsies
biopsy

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