The placental transfer of erythromycin in human pregnancies with group B streptococcal infection

Ginekologia polska
Magdalena BulskaDaria Orszulak-Michalak

Abstract

The aim of this study was to investigate the effectiveness of erythromycin in preventing fetal and intrauterine group B streptococcal (GBS) infections. The study evaluated the penetration of erythromycin through the placenta, by comparing umbilical vein and maternal serum erythromycin concentrations. The study subjects were 42 pregnant women, with GBS-positive screening or whose laboratory screening was not available, who delivered between 17th April 2013 and 22nd July 2013. The women were given 600 mg of erythromycin intravenously. After delivery blood was drawn from the mother's antecubital vein and umbilical cord vein. Serum erythromycin concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA) kit. The percentage and correlation between umbilical vein and maternal serum erythromycin concentration were calculated. Based on regression function parameters selected factors: maternal age, maternal body weight, gestational age at delivery related to the umbilical vein serum erythromycin concentration, were investigated. Results: A total of 42 umbilical vein-maternal serum pairs were included in the analysis. The mean umbilical vein-maternal serum erythromycin concentration percentage was 2.64 ± 1.55%. There wa...Continue Reading

Citations

May 30, 2019·Antimicrobial Resistance and Infection Control·Benjamin HetzerPeninnah Oberdorfer
Nov 14, 2019·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Narmeen MallahBahi Takkouche
Feb 7, 2021·Clinical Pharmacology and Therapeutics·Phoebe HazenbergCatriona Waitt
Jun 9, 2021·Pediatrics and Neonatology·Yao Zhu, Xin-Zhu Lin

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