The placental transfer of propylthiouracil, methimazole and carbimazole

The Journal of Clinical Endocrinology and Metabolism
B MarchantW D Alexander


The placental transfer of 35S-labelled methimazole (MMI), carbimazole and propylthiouracil (PTU) has been examined in the rat in late pregnancy and in patients undergoing therapeutic abortion. Although rapid equilibrium of fetal and maternal serum radioactivity (FS:MS ratio 1:1) occurred after iv administration of 35S-carbimazole or 35S-MMI in rats, a persistent fetal to maternal ratio of less than one was observed after 35S-PTU administration. Results from human studies after a single oral dose indicate that, as in the rat, the placenta appeared to be more permeable to 35S-MMI than to 35S-PTU as shown by the marked difference in fetal serum:maternal serum ratios and amounts accumulated in the fetus. Localization of radioactivity in the human fetal thyroid was also observed after administration of 35S-labelled MMI, carbimazole or PTU.


Jun 1, 1982·Klinische Wochenschrift·G Benker, D Reinwein
Aug 1, 1992·European Journal of Pediatrics·Z EisensteinH Bank
Apr 1, 1985·Pharmacology, Biochemistry, and Behavior·C P Comer, S Norton
Jan 1, 1981·Pharmacology & Therapeutics·W J Waddell, C Marlowe
Jun 1, 1995·Behavioural Brain Research·Sònia DarbraM A Marti-Carbonell
Mar 1, 1989·Neurotoxicology and Teratology·R R AlbeeW J Breslin
Mar 14, 2014·The Lancet. Diabetes & Endocrinology·D S Cooper, Peter Laurberg
May 23, 2007·Nature Clinical Practice. Endocrinology & Metabolism·Grace W Chan, Susan J Mandel
Mar 16, 2011·Nature Reviews. Endocrinology·Sofie BliddalUlla Feldt-Rasmussen
Dec 23, 1998·Clinical Endocrinology·N J Leech, C M Dayan
May 29, 2002·International Journal of Andrology·N KalaM M Aruldhas
Aug 29, 1985·The New England Journal of Medicine·G N Burrow
Mar 27, 1986·The New England Journal of Medicine·H Rosen
Dec 4, 1986·The New England Journal of Medicine
Feb 21, 1991·The New England Journal of Medicine·K M DavidsonD A Fisher
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·Susan J MandelP R Larsen
Aug 14, 1999·Thyroid : Official Journal of the American Thyroid Association·U S Masiukiewicz, G N Burrow
Oct 7, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mei-Chih ChenPaulus S Wang
Dec 16, 1998·Australian and New Zealand Journal of Medicine·R H Mortimer
Jan 31, 1987·British Medical Journal·P E Belchetz
Jan 5, 1999·BMJ : British Medical Journal·M J O'DohertyS H Thomas
Nov 1, 1985·The Journal of Clinical Investigation·M I CastroC H Emerson
Feb 9, 2012·Journal of Pediatric Endocrinology & Metabolism : JPEM·Leilei Yuan, Jigang Yang
Nov 28, 2012·European Journal of Endocrinology·Amnon ZungShlomo Almashanu
Jun 5, 2013·Neurotoxicology and Teratology·Andrew F M JohnstoneChristopher J Gordon
Sep 5, 2014·Journal of Endocrinological Investigation·Michele MarinòPaolo Vitti
Jan 1, 1990·Drug Metabolism Reviews·D S Sitar
Aug 20, 2008·Expert Opinion on Pharmacotherapy·Onyebuchi E OkosiemeJohn H Lazarus
Jan 1, 1994·American Journal of Obstetrics and Gynecology·D A WingJ H Mestman
Mar 13, 2013·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Manuel Gargallo Fernández
Mar 12, 2013·Physiology & Behavior·Masashi Hasegawa, Hiromi Wada
Nov 24, 2012·Placenta·S A DegrelleD Evain-Brion
Sep 14, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ibtissem Ben AmaraNajiba Zeghal
Jul 20, 2010·Neuroscience Letters·Masashi HasegawaHiromi Wada
May 18, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Ibtissem Ben AmaraNajiba Zeghal
Jul 21, 2009·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ibtissem Ben AmaraNajiba Zeghal
Jan 1, 2008·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Irene Halperin RabinovichCarles Villabona Artero
Aug 4, 2007·Endocrinology and Metabolism Clinics of North America·Bindu Nayak, Steven P Hodak
Nov 29, 2005·Endocrinology and Metabolism Clinics of North America·Shane O LeBeau, Susan J Mandel
Aug 2, 2008·Birth Defects Research. Part A, Clinical and Molecular Teratology·Lakshminarayanan KannanMadhulika Kabra
Jul 1, 1990·Trends in Endocrinology and Metabolism : TEM·D L Ewins, A M McGregor
Sep 1, 1992·Baillière's Clinical Obstetrics and Gynaecology·R M Silver, D W Branch
Jun 4, 2010·Acta Biologica Hungarica·Ibtissem Ben AmaraNajiba Zeghal
Jul 28, 2004·Physiology & Behavior·Sònia DarbraAdriana Garau
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed
Oct 27, 2016·Expert Review of Clinical Pharmacology·I KhanJohn H Lazarus
May 17, 2007·The Annals of Pharmacotherapy·Jeanne M Chattaway, Teresa B Klepser
Jul 5, 2003·The Annals of Pharmacotherapy·Darcie D Streetman, Ujjaini Khanderia
Oct 14, 1987·Biochemical and Biophysical Research Communications·M J ObregonB Cannon
Aug 2, 2002·Journal of Endocrinological Investigation·F AziziM Hedayati
Oct 4, 2017·Toxicological Sciences : an Official Journal of the Society of Toxicology·Iman HassanMary E Gilbert
Feb 11, 2004·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·N Yanai, D Shveiky
Jun 1, 1994·The Australian & New Zealand Journal of Obstetrics & Gynaecology·W R Jones
Oct 16, 2018·European Journal of Endocrinology·Henry B Burch, D S Cooper
Jun 25, 2010·Endocrine Reviews·G E KrassasD Glinoer
Apr 1, 2020·Expert Opinion on Drug Safety·Thanuya FrancisOnyebuchi E Okosieme
Sep 1, 1997·The Journal of Clinical Endocrinology and Metabolism·R H MortimerI Bernus
Jul 1, 2010·Expert Review of Endocrinology & Metabolism·Onyebuchi E Okosieme, John H Lazarus
Mar 1, 1997·Clinical Obstetrics and Gynecology·J H Mestman
Apr 29, 1999·Current Opinion in Obstetrics & Gynecology·J H Mestman
Dec 1, 1990·Journal of Endocrinological Investigation·C Y HayashidaE H Yamashiro-Kanashiro
Apr 15, 2000·Scottish Medical Journal·A Jamieson, C G Semple
Sep 27, 2000·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·P AtkinsB J Phillips
Nov 22, 1984·The New England Journal of Medicine·D S Cooper

Related Concepts

Abortion Failure
Neo Tomizol
Maternal-Fetal Exchange

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

The Journal of Clinical Endocrinology and Metabolism
Susanne NeumannMarvin C Gershengorn
European Journal of Endocrinology
F Azizi, Atieh Amouzegar
Annals of Internal Medicine
A Rizvi, L M Crapo
© 2021 Meta ULC. All rights reserved