The planarian TRPA1 homolog mediates extraocular behavioral responses to near-ultraviolet light

The Journal of Experimental Biology
Taylor R Birkholz, Wendy S Beane

Abstract

Although light is most commonly thought of as a visual cue, many animals possess mechanisms to detect light outside of the eye for various functions, including predator avoidance, circadian rhythms, phototaxis and migration. Here we confirm that planarians (like Caenorhabditis elegans, leeches and Drosophila larvae) are capable of detecting and responding to light using extraocular photoreception. We found that, when either eyeless or decapitated worms were exposed to near-ultraviolet (near-UV) light, intense wild-type photophobic behaviors were still observed. Our data also revealed that behavioral responses to green wavelengths were mediated by ocular mechanisms, whereas near-UV responses were driven by extraocular mechanisms. As part of a candidate screen to uncover the genetic basis of extraocular photoreception in the planarian species Schmidtea mediterranea, we identified a potential role for a homolog of the transient receptor potential channel A1 (TRPA1) in mediating behavioral responses to extraocular light cues. RNA interference (RNAi) to Smed-TrpA resulted in worms that lacked extraocular photophobic responses to near-UV light, a mechanism previously only identified in Drosophila These data show that the planarian TR...Continue Reading

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Citations

Jun 13, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Siqi ZhangEva-Maria S Collins
Nov 2, 2019·Physiological Reviews·Karel TalaveraBernd Nilius
Nov 14, 2019·Zoological Letters·Masato MoriTakeshi Inoue
Dec 29, 2017·Neuroscience Bulletin·Carlene MooreWolfgang B Liedtke
Feb 8, 2019·Science Advances·Alanna V Van HuizenWendy S Beane
Dec 4, 2019·Trends in Parasitology·Sang-Kyu Park, Jonathan S Marchant
May 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Nishan ShettigarAkash Gulyani

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