The plant-specific function of 2-Cys peroxiredoxin-mediated detoxification of peroxides in the redox-hierarchy of photosynthetic electron flux

Proceedings of the National Academy of Sciences of the United States of America
Janine KönigKarl-Josef Dietz

Abstract

The 2-cysteine peroxiredoxins (2-Cys Prx) constitute an ancient family of peroxide detoxifying enzymes and have acquired a plant-specific function in the oxygenic environment of the chloroplast. Immunocytochemical analysis and work with isolated intact chloroplasts revealed a reversible binding of the oligomeric form of 2-Cys Prx to the thylakoid membrane. The oligomeric form of the enzyme was enhanced under stress. The 2-Cys Prx has a broad substrate specificity with activity toward hydrogen peroxides and complex alkyl hydroperoxides. During the peroxide reduction reaction, 2-Cys Prx is alternatively oxidized and reduced as it catalyzes an electron flow from an electron donor to peroxide. Escherichia coli thioredoxin, but also spinach thioredoxin f and m were able to reduce oxidized 2-Cys Prx. The midpoint redox potential of -315 mV places 2-Cys Prx reduction after Calvin cycle activation and before switching the malate valve for export of excess reduction equivalents to the cytosol. Thus the 2-Cys Prx has a defined and preferential place in the hierarchy of photosynthetic electron transport. The activity of 2-Cys Prx also is linked to chloroplastic NAD(P)H metabolism as indicated by the presence of the reduced form of the enz...Continue Reading

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Citations

Oct 5, 2013·Analytical and Bioanalytical Chemistry·Anna Laura CapriottiAldo Laganà
Apr 14, 2007·Current Genetics·Stéphane D LemaireEmmanuelle Issakidis-Bourguet
Nov 8, 2006·Photosynthesis Research·Laure MicheletStéphane D Lemaire
Nov 8, 2006·Photosynthesis Research·Valérie Noguera-MazonJean-Marc Lancelin
Jan 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Derek ParsonageLeslie B Poole
Apr 29, 2011·The Journal of Biological Chemistry·Martín AranRicardo A Wolosiuk
Mar 11, 2003·Antioxidants & Redox Signaling·Peter Schürmann
Apr 2, 2008·Antioxidants & Redox Signaling·Peter Schürmann, Bob B Buchanan
Jul 29, 2009·Antioxidants & Redox Signaling·Merridee A WoutersNaomi L Haworth
Jan 5, 2011·Antioxidants & Redox Signaling·Karl-Josef Dietz
Jan 8, 2013·Antioxidants & Redox Signaling·Thomas Kieselbach
Jan 9, 2009·Journal of Experimental Botany·Margit BernroitnerChristian Obinger
Feb 24, 2010·Journal of Experimental Botany·Iván Iglesias-BaenaJuan-José Lázaro
Jul 10, 2010·Journal of Experimental Botany·Pablo PulidoFrancisco Javier Cejudo
Sep 30, 2010·Journal of Experimental Botany·Amna MhamdiGraham Noctor
Jul 6, 2013·Journal of Experimental Botany·Janine KönigKarl-Josef Dietz
Sep 16, 2003·Plant Physiology·Patricia Müller-MouléKrishna K Niyogi
Feb 21, 2004·Plant Physiology·Nicolas RouhierJean-Pierre Jacquot
Jun 8, 2004·Plant Physiology·Michael BauerJutta Papenbrock
Nov 9, 2004·Plant Physiology·Valérie CollinEmmanuelle Issakidis-Bourguet
Aug 8, 2006·The Plant Cell·Juan Manuel Pérez-RuizFrancisco Javier Cejudo
Dec 22, 2004·The Plant Journal : for Cell and Molecular Biology·Pascal ReyMélanie Broin
Sep 25, 2003·Annual Review of Plant Biology·Karl-Josef Dietz

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