PMID: 3745704Sep 1, 1986Paper

The plasma catecholamine response to ventricular tachycardia induction and external countershock during electrophysiologic testing

Journal of the American College of Cardiology
F MoradyJ M Baerman

Abstract

Adrenergic activation during electrophysiologic study could potentially alter the electrophysiologic properties of the arrhythmia substrate. However, the catecholamine response to ventricular tachycardia induction and termination during electrophysiologic testing has to date not been quantitated. Therefore, in 13 patients undergoing electrophysiologic study, arterial plasma norepinephrine and epinephrine were measured before, during and 1, 3, 5, 10 and 15 minutes after ventricular tachycardia induced by programmed stimulation and terminated by a single 100 J external countershock. Sinus rate and the effective refractory period at the right ventricular apex at a basic drive cycle length of 400 ms were measured after the countershock at the same time intervals used for the catecholamine measurements. The mean ventricular tachycardia cycle length (+/- SD) was 187 +/- 30 ms, and the mean duration of ventricular tachycardia was 18 +/- 4 seconds. Plasma norepinephrine and epinephrine increased, respectively, from a baseline of 286 +/- 141 and 119 +/- 40 pg/ml to 770 +/- 330 (169%) and 597 +/- 467 pg/ml (402%), (p less than 0.01) at 1 minute after the countershock. The mean plasma norepinephrine and epinephrine levels during ventricul...Continue Reading

References

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Citations

Feb 1, 1994·Journal of Clinical Pharmacology·R T BrautigamS P Kutalek
Jun 1, 1989·Journal of the American College of Cardiology·M J CooperD L Ross
Nov 1, 1990·Pacing and Clinical Electrophysiology : PACE·S RosenheckF Morady
Sep 1, 1993·Pacing and Clinical Electrophysiology : PACE·D M SalernoK Fjeldos-Sperbeck
Jun 1, 1993·Journal of Cardiovascular Electrophysiology·P Coumel
Jun 1, 1991·American Heart Journal·T J Cohen, L B Liem
Feb 15, 1990·The American Journal of Cardiology·H D GössingerH Mösslacher
Mar 1, 1989·The American Journal of Cardiology·I G CrozierM G Nicholls
Feb 15, 1992·The American Journal of Cardiology·J SousaF Morady

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