PMID: 7527644Jul 1, 1994Paper

The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils

British Journal of Haematology
T W HuizingaA E von dem Borne

Abstract

Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils.

References

Dec 1, 1979·British Journal of Haematology·J H ReijdenC P Engelfriet
Apr 7, 1977·The New England Journal of Medicine·P R CraddockH S Jacob
Aug 1, 1990·The Journal of Clinical Investigation·T W HuizingaA E von dem Borne
Dec 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·B I LordT M Dexter
May 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·H B FleitJ C Unkeless

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Citations

Aug 10, 2000·British Journal of Haematology·R Carr
Jul 27, 2001·Clinical and Experimental Immunology·P J MiddelhovenD Roos
May 3, 2011·The Journal of Biological Chemistry·Achim BoltzBjoern Hock
Feb 1, 1996·Journal of Clinical Pathology·J MeenanS J van Deventer
Feb 27, 1999·Leukemia & Lymphoma·C MathiotC Sautès
Jan 1, 1997·International Reviews of Immunology·H RouardJ L Teillaud
Dec 12, 2012·Biochimica Et Biophysica Acta·Yue WangBruce Walcheck
Dec 25, 2009·Molecular Immunology·Deepak K NayakEva Bengtén
Aug 5, 2009·PLoS Neglected Tropical Diseases·Suman K VodnalaMartin E Rottenberg
Aug 25, 2016·PLoS Neglected Tropical Diseases·Veronica SchmitzEuzenir Nunes Sarno
Mar 19, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Sofia E MagnussonSandra Kleinau
Aug 18, 2018·Pediatric Blood & Cancer·Jan Palmblad, Petter Höglund
Aug 21, 2009·ChemSusChem·Benjamin KatryniokFranck Dumeignil
Oct 14, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yuichi TanakaYasuhiko Tomino
Jan 1, 1997·International Reviews of Immunology·I A Heijnen, J G van de Winkel
Sep 26, 1997·FEBS Letters·P J MiddelhovenA J Verhoeven
Nov 20, 1998·Clinical and Experimental Immunology·A C Muller KoboldJ W Tervaert
Jan 1, 1997·International Reviews of Immunology·J GalonC Sautès

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