PMID: 7011723Mar 1, 1981Paper

The plasma glucose response of normal fasting subjects to neutral regular and NPH biosynthetic human and purified pork insulins

Diabetes Care
J A GallowayS E Fineberg

Abstract

Using doses of 0.1 and 0.15 U/kg, the hypoglycemic activities of neutral regular and NPH biosynthetic human insulin (BHI) and purified pork insulin were compared in normal fasting subjects. Neutral regular insulin was administered by the intravenous and subcutaneous routes and NPH subcutaneously. Comparison of the plasma glucose curves disclosed no statistically significant differences between the maximum effects and the length of time to achieve the maximum effect. Moreover, a dose-response difference between 0.1 and 0.15 U/kg could not established. It is concluded that the hypoglycemic activities of neutral regular and NPH BHI and purified pork insulin are the same.

Citations

Jan 5, 2002·Diabetes Technology & Therapeutics·M K FrohnauerJ H Anderson
Oct 1, 1995·Clinical Pharmacology and Therapeutics·D C HoweyJ R Woodworth
Jan 1, 1994·Journal of Ocular Pharmacology·J D BartlettD J Pillion

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