The plasminogen receptor, Plg-RKT, is essential for mammary lobuloalveolar development and lactation

Journal of Thrombosis and Haemostasis : JTH
Lindsey A MilesRobert J Parmer

Abstract

Essentials Plg-RKT-/- female mice give birth, but no offspring of Plg-RKT-/- female mice survive to weaning. Causal mechanisms of potential lactational failure in Plg-RKT-/- mice are unknown. Plg-RKT regulates extracellular matrix remodeling, cell proliferation, apoptosis, fibrin surveillance. Plg-RKT is essential for lactogenesis and mammary lobuloalveolar development. Background Lactational competence requires plasminogen, the zymogen of the serine protease, plasmin. Plg-RKT is a unique transmembrane plasminogen receptor that promotes plasminogen activation to plasmin on cell surfaces. Plg-RKT-/- mice are viable, but no offspring of Plg-RKT-/- female mice survive to weaning. Objectives We investigated potential lactational failure in Plg-RKT-/- mice and addressed causal mechanisms. Methods Fibrin accumulation, macrophage infiltration, processing of extracellular matrix components, effects of genetic deletion of fibrinogen, expression of fibrosis genes, and proliferation and apoptosis of epithelial cells were examined in lactating mammary glands of Plg-RKT-/- and Plg-RKT+/+ mice. Results Milk was not present in the stomachs of offspring of Plg-RKT-/- female mice and the pups were rescued by foster mothers. Although the mammary...Continue Reading

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Citations

Jul 15, 2020·Journal of Thrombosis and Haemostasis : JTH·Lindsey A MilesRobert J Parmer
Feb 12, 2021·International Journal of Molecular Sciences·Lindsey A MilesRobert J Parmer
Dec 14, 2021·Journal of Thrombosis and Haemostasis : JTH·Fahumiya SamadLindsey A Miles

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