The plastic brain: neurotoxicity of micro- and nanoplastics.

Particle and Fibre Toxicology
Minne PrüstRemco H S Westerink

Abstract

Given the global abundance and environmental persistence, exposure of humans and (aquatic) animals to micro- and nanoplastics is unavoidable. Current evidence indicates that micro- and nanoplastics can be taken up by aquatic organism as well as by mammals. Upon uptake, micro- and nanoplastics can reach the brain, although there is limited information regarding the number of particles that reaches the brain and the potential neurotoxicity of these small plastic particles.Earlier studies indicated that metal and metal-oxide nanoparticles, such as gold (Au) and titanium dioxide (TiO2) nanoparticles, can also reach the brain to exert a range of neurotoxic effects. Given the similarities between these chemically inert metal(oxide) nanoparticles and plastic particles, this review aims to provide an overview of the reported neurotoxic effects of micro- and nanoplastics in different species and in vitro. The combined data, although fragmentary, indicate that exposure to micro- and nanoplastics can induce oxidative stress, potentially resulting in cellular damage and an increased vulnerability to develop neuronal disorders. Additionally, exposure to micro- and nanoplastics can result in inhibition of acetylcholinesterase activity and al...Continue Reading

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Aug 12, 2020·ChemSusChem·Roman ElfgenOldamur Hollóczki
Dec 23, 2020·Journal of Hazardous Materials·Abraão Tiago Batista GuimarãesGuilherme Malafaia
Jan 22, 2021·Environmental Science. Processes & Impacts·Chloe Wayman, Helge Niemann
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Aug 5, 2021·The Science of the Total Environment·Monica Torres-RuizAna Isabel Cañas Portilla
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Oct 11, 2021·The Science of the Total Environment·Wookbong KwonSeong-Kyoon Choi
Jan 22, 2022·Chemical Research in Toxicology·Xiangyu ZhuYang Song

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Methods Mentioned

BETA
confocal microscopy
optical
infrared spectroscopy
light microscopy
fluorescence microscopy
MDA
fluorescence imaging
flow cytometry

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