The plastic cellular states of liver cells: Are EpCAM and Lgr5 fit for purpose?

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
Meritxell Huch, Laurent Dollé

Abstract

Adult liver cells have been considered restricted regarding their fate and lineage potential. That is, hepatocytes have been thought able only to generate hepatocytes and duct cells, only duct cells. While this may be the case for the majority of scenarios in a state of quiescence or homeostasis, evidence suggests that liver cells are capable of interconverting between cellular states of distinct phenotypic traits. This interconversion or plasticity had been suggested by classical studies using cellular markers, but recently lineage tracing approaches have proven that cells are highly plastic and retain an extraordinary ability to respond differently to normal tissue homeostasis, to tissue repair, or when challenged to expand ex vivo or to differentiate upon transplantation. Stemness, as "self-renewal and multipotency," seems not to be limited to a particular cell type but rather to a cellular state in which cells exhibit a high degree of plasticity and can move back and forth in different phenotypic states. For instance, upon damage cells can dedifferentiate to acquire stem cell potential that allows them to self-renew, repopulate a damaged tissue, and then undergo differentiation. In this review, we will discuss the evidence ...Continue Reading

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Citations

Apr 23, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Lola M Reid
Jul 2, 2016·Developmental Biology·Christopher J HindleyMeritxell Huch
Dec 21, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·George K Michalopoulos
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Jan 3, 2018·The Journal of Clinical Investigation·Lucía Cordero-Espinoza, Meritxell Huch
Mar 2, 2021·Seminars in Cancer Biology·Lo-Kong ChanIrene Oi-Lin Ng
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Feb 28, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Junya ShiotaNataliya Razumilava
Jul 29, 2021·ACS Biomaterials Science & Engineering·Aarushi SharmaSourabh Ghosh

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Methods Mentioned

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