The plastic d-serine signaling pathway: Sliding from neurons to glia and vice-versa

Neuroscience Letters
Andrei D Ivanov, Jean-Pierre Mothet

Abstract

d-Serine is now recognized as the main co-agonist for NMDA receptors. For years it was thought to be exclusively produced by astrocytes and was thus viewed as the archetype of gliotransmitters. Recent research have challenged this long cherished and appealing view by showing that in physiological conditions d-erine would rather originate from neurons but not from glia. In the present review and in the light of the emerging serine shuttle model, we ambition to offer a new reading direction of the glia-neuron cross-talk in shaping the metabolism and the functions of d-serine in cerebral communication in normal and pathological conditions by re-interpretating some seminal findings.

Citations

Dec 17, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·F Rob JacksonLauren B Crowe
Jul 10, 2020·The European Journal of Neuroscience·Celia RomanBarbara Di Benedetto
Jul 31, 2018·Frontiers in Molecular Neuroscience·Ulyana LaloYuriy Pankratov
Sep 25, 2019·Proceedings of the National Academy of Sciences of the United States of America·Samah NeameHerman Wolosker
Feb 16, 2019·Neurochemical Research·Alexei Verkhratsky, Alexandr Chvátal
May 1, 2021·International Journal of Molecular Sciences·Giulia MurtasLoredano Pollegioni
Jul 2, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marlene F PereiraPaula Agostinho
Aug 26, 2021·Neuropharmacology·Ulyana LaloYuriy Pankratov
Aug 28, 2021·Frontiers in Psychiatry·Amir MeftahJoshua T Kantrowitz

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