Abstract
To examine changes in subpopulation of CD4+CD25+Foxp3+CD127low T lymphocytes (Treg) and their association with the efficiency of the IFN-α therapy. Pts with mRCC who had undergone nephrectomy were treated with IFN-α at a dose of 6 × 106 U/day three times a week (n = 18). An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN-α therapy and 22 normal volunteers. Blood samples were collected at baseline and 2 mo after treatment start. Serum levels of TGF-β1, IL-17A, and Epo were measured by ELISA. PR was achieved in 3 (16.6%) pts who received first-line therapy. Long-lasting SD (≥6 months) was noted in 6 (33.3%) pts. The median progression free survival (PFS) was 4 mo (95% CI: 2-NE). The study of the population of Treg indicated that there were no significant differences in the groups depending on the effect (p = 0.71). In one patient, the reduction of Treg cells was associated with increased TGF-β and IL-17 levels, whereas in other two pts the increase in Treg cells was associated with decreased TGF-β and IL-17 levels. The endogenous levels of Epo did not show significant correlation with response to IFN-α imm...Continue Reading
References
Jan 1, 1992·Cancer Immunology, Immunotherapy : CII·M R YoungJ Bagash
Nov 1, 1993·Cancer·J E JanikJ W Smith
May 20, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C Lacombe, P Mayeux
Jan 25, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Paul L KimmelTerry M Phillips
Dec 5, 2003·American Journal of Nephrology·Mindy A Maynard, Michael Ohh
Feb 14, 2006·Immunity·Marc VeldhoenBrigitta Stockinger
Mar 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni C CesanaHoward L Kaufman
May 2, 2006·Nature·Paul R ManganCasey T Weaver
May 2, 2006·Nature·Estelle BettelliVijay K Kuchroo
Jun 20, 2006·Biochimica Et Biophysica Acta·Paul E HarrisAntonella Maffei
May 29, 2007·Biochimie·Maria FerrantiniFilippo Belardelli
Jan 10, 2009·Annual Review of Immunology·Thomas KornVijay K Kuchroo
Mar 11, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kui Shin VooYong-Jun Liu
Apr 16, 2009·Blood·Madhav D SharmaDavid H Munn
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wendy A GoodmanKevin D Cooper
Jun 29, 2010·European Journal of Immunology·Akihiro Kimura, Tadamitsu Kishimoto
Dec 18, 2010·Annals of Dermatology·Woo-Jin YunJee-Ho Choi
Aug 30, 2011·Cell·Eric V DangFan Pan
Jun 4, 2015·Clinics·Karina de Oliveira PeliçariSimone Appenzeller
Nov 20, 2015·BioMed Research International·Leslie Guéry, Stéphanie Hugues