The plasticizer benzyl butyl phthalate (BBP) alters the ecdysone hormone pathway, the cellular response to stress, the energy metabolism, and several detoxication mechanisms in Chironomus riparius larvae

Chemosphere
Oscar HerreroGloria Morcillo

Abstract

Butyl benzyl phthalate (BBP) has been extensively used worldwide as a plasticizer in the polyvinyl chloride (PVC) industry and the manufacturing of many other products, and its presence in the aquatic environment is expected for decades. In the present study, the toxicity of BBP was investigated in Chironomus riparius aquatic larvae. The effects of acute 24-h and 48-h exposures to a wide range of BBP doses were evaluated at the molecular level by analysing changes in genes related to the stress response, the endocrine system, the energy metabolism, and detoxication pathways, as well as in the enzyme activity of glutathione S-transferase. BBP caused a dose and time-dependent toxicity in most of the selected biomarkers. 24-h exposures to high doses affected larval survival and lead to a significant response of several heat-shock genes (hsp70, hsp40, and hsp27), and to a clear endocrine disrupting effect by upregulating the ecdysone receptor gene (EcR). Longer treatments with low doses triggered a general repression of transcription and GST activity. Furthermore, delayed toxicity studies were specially relevant, since they allowed us to detect unpredictable toxic effects, not immediately manifested after contact with the phthalate...Continue Reading

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Citations

Mar 12, 2016·Aquatic Toxicology·Mónica AquilinoJosé-Luis Martínez-Guitarte
Mar 21, 2016·The Science of the Total Environment·Irene OzáezJosé-Luis Martínez-Guitarte
Apr 19, 2016·Environmental Pollution·Irene OzáezJosé-Luis Martínez-Guitarte
Jun 25, 2017·Chemosphere·Ali Karami
Oct 17, 2017·Environmental Science and Pollution Research International·Raquel Martín-FolgarJosé-Luis Martínez-Guitarte
Oct 24, 2018·Environmental Science and Pollution Research International·Ana-Belén Muñiz-González, José-Luis Martínez-Guitarte
Nov 2, 2019·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Chaitali M Shaha, Radhakrishna S Pandit
Feb 7, 2021·The Science of the Total Environment·Ying ZhangYang Yang
Feb 12, 2020·The Science of the Total Environment·Gisele Dos Santos MoraisMário Antônio Navarro da Silva
Jan 22, 2020·Molecular and Cellular Endocrinology·Virginie Cuvillier-Hot, Alain Lenoir
May 24, 2021·Environmental Science and Pollution Research International·Hamidreza Mohammadi, Sorour Ashari
Jun 3, 2021·Scientific Reports·Marina Prieto-AmadorJosé-Luis Martínez-Guitarte
Jun 7, 2021·Environmental Pollution·Victor Carrasco-NavarroJose-Luis Martínez-Guitarte
Jun 30, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Juan C Sanchez-Hernandez
Sep 14, 2021·Environmental Science and Pollution Research International·Mercedes de la FuenteMónica Morales

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