PMID: 7372373Apr 15, 1980Paper

The plate-implant as a bioassay for the neoplastic potential of cultured cells

International Journal of Cancer. Journal International Du Cancer
K K SanfordC U Garrison

Abstract

One objective of this study was to test the plate implant as an in vivo bioassay for the neoplastic state with pairs of cell lines that were non-tumorigenic and tumorigenic when inoculated in suspension at various sites. Each pair originated from a common cell pool or from one cell derived from normal rat or mouse embryonic tissue. The implantation of cells attached to polycarbonate plates was compared with the subcutaneous injection of comparable numbers of cells in suspension or the intraocular injection of 10(5) cells. In addition, some implants of glass helices with attached cells were made into syngeneic mice and compared with injection of comparable cell numbers intramuscularly into X-irradiated hosts. A total of 10 lines or clones were tested on plates. Of four lines that were non-tumorigenic when inoculated in suspension either subcutaneously or intraocularly, two were tumorigenic when implanted subcutaneously attached to plastic plates. The remaining two are the first permanent rodent lines that have not been tumorigc on plastic plates. Of the remaining six lines, all were tumorigenic on plates and two produced sarcomas at a higher frequency on plates than in suspension. Cytologic diagnoses of the cells implanted on pl...Continue Reading

References

Jan 1, 1975·Journal of the National Cancer Institute·W E LaugW F Benedict
Nov 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·S I ShinR Pollack
Sep 1, 1977·In Vitro·S L HandlemanR Parshad
Jan 1, 1977·Experimental Cell Research·R ParshadW G Taylor
Jun 1, 1977·Journal of the National Cancer Institute·C J MarshallA W Carbonell
Jul 1, 1975·Experimental Cell Research·M S ParanjpeS del Ande Eaton
Nov 27, 1974·Biochemical and Biophysical Research Communications·D M MottS Sorof
Nov 1, 1974·Journal of the National Cancer Institute·K K Sanford
May 1, 1970·The Journal of Cell Biology·A L Horwitz, A Dorfman
Jan 1, 1965·International Review of Cytology·K K Sanford
Jan 1, 1964·Progress in Experimental Tumor Research·F BISCHOFF, G BRYSON

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Citations

Jan 1, 1983·Clinical & Experimental Metastasis·C MeyvischM M Mareel
Jan 1, 1981·Virchows Archiv. B, Cell Pathology Including Molecular Pathology·M M MareelC Dragonetti
Dec 1, 1982·Journal of Cellular Physiology·C Krycève-MartinerieP Vigier
Sep 15, 1986·International Journal of Cancer. Journal International Du Cancer·C W BooneG M Jones

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