The platelet activating factor receptor is not required for exacerbation of bacterial pneumonia following influenza

Scandinavian Journal of Infectious Diseases
Jonathan A McCullersPeter J Murray

Abstract

Pneumonia caused by Streptococcus pneumoniae is a significant cause of morbidity and mortality during influenza virus epidemics. We had previously advanced the hypothesis that interactions of pneumococcus with the receptor for platelet activating factor (PAFR) in the lung were facilitated by antecedent influenza virus infection and play a major role in the pathogenesis of bacterial superinfections. Although influenza enhanced the adherence of pneumococci to respiratory epithelial cells in vitro, chemical or antibody-mediated blockade of the PAFR did not affect adherence. In agreement with these data, mice lacking PAFR had similar bacterial loads within the lung compartment when compared to heterozygous littermates and were not protected from secondary pneumococcal pneumonia after influenza. Lack of support for this hypothesis and the observation of enhanced inflammation during secondary pneumococcal pneumonia in mice lacking PAFR may moderate enthusiasm for treatment strategies targeting the interaction of bacteria with PAFR.

References

Nov 1, 1986·The American Review of Respiratory Disease·M C PlotkowskiC Hannoun
Jul 17, 1998·The Journal of Clinical Investigation·A RingElaine Tuomanen
Oct 17, 2002·British Journal of Pharmacology·A C SoaresMauro M Teixeira
Jan 9, 2003·JAMA : the Journal of the American Medical Association·William W ThompsonKeiji Fukuda
Feb 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Richard MalleyDouglas T Golenbock
Mar 28, 2003·The Journal of Infectious Diseases·Jonathan A McCullers, Kimberly C Bartmess
Jun 7, 2003·BMJ : British Medical Journal·Klaus Stöhr
Jan 1, 1959·The Journal of Clinical Investigation·D B LOURIAD E ROGERS
Apr 1, 1959·A.M.A. Archives of Internal Medicine·C M MARTINM FINLAND
Nov 19, 2003·Scandinavian Journal of Infectious Diseases·Carlos J OrihuelaElaine Tuomanen
Feb 10, 2004·The Journal of Infectious Diseases·Anita W RijneveldTom van der Poll
Jun 18, 2005·The Journal of Infectious Diseases·Ville T PeltolaJonathan A McCullers
Aug 16, 2005·American Journal of Physiology. Lung Cellular and Molecular Physiology·Koenraad F van der SluijsTom van der Poll
Oct 8, 2005·Science·Terrence M TumpeyAdolfo García-Sastre
Jun 23, 2006·Infection and Immunity·Carlos J OrihuelaElaine Tuomanen
Jul 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susana E MorenoMauro M Teixeira
Jul 19, 2006·Clinical Microbiology Reviews·Jonathan A McCullers
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sophie FillonElaine Tuomanen
Jan 1, 1949·The Journal of Experimental Medicine·C G HARFORDM HARA

Citations

Jul 8, 2011·Clinical Microbiology Reviews·Barry B Mook-KanamoriDiederik van de Beek
Jan 15, 2011·Clinical Microbiology Reviews·Marjolaine VareilleNicolas Regamey
Jan 13, 2010·Clinical Microbiology Reviews·John S Tregoning, Jürgen Schwarze
May 13, 2010·Critical Care : the Official Journal of the Critical Care Forum·Koenraad F van der SluijsMarcus J Schultz
Dec 19, 2009·The American Journal of Pathology·Kevan L Hartshorn
Oct 1, 2008·Expert Review of Respiratory Medicine·Shabir Ahmed MadhiKeith P Klugman
Dec 2, 2016·The Journal of General Virology·Carla BellinghausenFrank R M Stassen
Aug 22, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dennis W Metzger, Keer Sun
Feb 18, 2011·The Journal of General Virology·Anna GoldaKrzysztof Pyrc
Jul 11, 2017·Frontiers in Microbiology·Denise E MorrisStuart C Clarke

Related Concepts

Platelet activating factor receptor
Bacterial Adhesion
Orthomyxoviridae Infections
Platelet Membrane Glycoproteins
Streptococcal Pneumonia
Streptococcus pneumoniae
Superinfection
Mice, Knockout
G-Protein-Coupled Receptors
Influenza A Virus, H1N1 Subtype

Related Feeds

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.