The platelet-independent release of thromboxane A2 by Paf-acether from guinea-pig lungs involves mechanisms distinct from those for leukotriene

British Journal of Pharmacology
J LefortB B Vargaftig

Abstract

Intra-arterial injections of platelet-activating factor (Paf-acether, 10-300 ng) to the perfused guinea-pig lung induced a dose-related bronchoconstriction, followed by contraction of the rat aorta superfused with the lung effluent, indicating the release of thromboxane A2 (TXA2) activity. These effects were matched with injections of bradykinin (Bk) at 100-1000 ng, leukotriene C4(LTC4) at 10-300 ng or arachidonic acid (AA) at 30-300 micrograms. Repeated doses of Paf-acether led to a specific desensitization of the release of TXA2, under conditions where Bk, LTC4 and arachidonic acid retained their ability to release TXA2. Bronchoconstriction and the release of TXA2 induced by Paf-acether were suppressed when the lungs were perfused with acetylsalicylic acid, but not with salicylic acid. The phospholipase A2 inhibitor, p-bromophenacyl bromide suppressed the release of TXA2 by Bk, but did not interfere with its formation from AA, nor with its release with Paf-acether and LTC4. The lipoxygenase inhibitor, nordihydroguaiaretic acid, inhibited to a similar extent the release of TXA2 by Bk, LTC4 and Paf-acether but also reduced directly the formation of TXA2 from arachidonic acid, invalidating its use as a specific antilipoxygenase ...Continue Reading

References

Nov 29, 1978·Biochemical and Biophysical Research Communications·N K HopkinsR R Gorman
Oct 1, 1979·The Journal of Physiology·F Al-Ubaidi, Y S Bakhle
Feb 14, 1973·Biochimica Et Biophysica Acta·R FransonP Elsbach
Mar 26, 1974·Biochemistry·J J VolwerkG H de Haas
May 27, 1982·Nature·J A RankinP W Askenase
Feb 1, 1983·Biochemical Pharmacology·P BorgeatJ Maclouf
Mar 7, 1980·European Journal of Pharmacology·F Al-Ubaidi, Y S Bakhle
Jul 10, 1981·European Journal of Pharmacology·B B VargaftigR C Murphy
Jan 1, 1981·Annals of the New York Academy of Sciences·B B VargaftigF Wal
Jul 1, 1981·Pharmacological Research Communications·C OminiF Berti
Feb 1, 1953·Archives of Biochemistry and Biophysics·A L TAPPELP D BOYER
Apr 1, 1963·British Journal of Pharmacology and Chemotherapy·H O COLLIER, P G SHORLEY
Aug 1, 1964·British Journal of Pharmacology and Chemotherapy·P A BERRY, H O COLLIER

Citations

Oct 1, 1995·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·G EngelhardtC Schnitzler
Jun 12, 1987·European Journal of Pharmacology·J EgidoL Hernando
Jun 10, 1988·European Journal of Pharmacology·J LefortB B Vargaftig
Jun 20, 1989·European Journal of Pharmacology·J S FranzoneP Biffignandi
Jun 1, 1988·The Journal of Allergy and Clinical Immunology·K F ChungP J Barnes
Jan 1, 1989·Pharmacology & Therapeutics·J MorleyI D Chapman
Jan 1, 1995·Journal of Lipid Mediators and Cell Signalling·M SaitoT Matsuda
Dec 1, 1992·British Journal of Pharmacology·K TashiroY Ito
Sep 1, 1986·Acta Physiologica Scandinavica·F KröllA Ryrfeldt
Jun 1, 1989·British Journal of Pharmacology·S BrunelleschiJ Benveniste
May 1, 1986·British Journal of Pharmacology·M F FitzgeraldL Parente
Apr 1, 1985·British Journal of Pharmacology·A DetsouliB B Vargaftig
Jan 1, 1989·British Journal of Pharmacology·S JancarP Sirois
May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.