PMID: 9186540Apr 1, 1997Paper

The platelet proaggregating and potentiating effects of unfractionated heparin, low molecular weight heparin and heparinoid in intensive care patients and healthy controls

European Journal of Haematology
J K Burgess, B H Chong

Abstract

Heparin binds to platelets and can cause platelet proaggregating and potentiating effects, possibly causing thrombocytopenia, particularly in patients in intensive care with hyperaggregable platelets. In this study we compared the platelet proaggregating and potentiating effects of unfractionated heparin (UH), 2 low molecular weight (LMW) heparins, enoxaparin and dalteparin, and a heparinoid, danaparoid sodium (orgaran), to platelets of an ICU patient population and a normal control group. In both populations UH caused platelet aggregation in a dose-dependent manner. This occurred in the therapeutic range of the drug, with as little as 0.5 U/ml UH. The LMW heparins caused less and the heparinoid least platelet aggregation. Generally, the aggregation observed in ICU patients was greater than in the normal population. The potentiating effects of the 4 drugs in association with physiological agonists was examined. Similar patterns of potentiation were observed in both populations, with UH causing significant enhancement of platelet aggregation, the LMW heparins intermediate and heparinoid least enhancement. There was substantial variability in the individuals' platelets' reactions to the drugs, in particular to UH. Our findings su...Continue Reading

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Citations

Feb 26, 2004·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shunji SuzukiTakefumi Matsuo
Nov 13, 2001·Reviews in Clinical and Experimental Hematology·A GreinacherV Kiefel
Sep 27, 2006·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Efthymios N DeliargyrisDavid C Sane
Sep 7, 2007·Clinical Cardiology·Gilead I LancasterStuart W Zarich
Dec 15, 2017·Pediatric Transplantation·Koji KatoKimikazu Matsumoto
Jul 18, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·J F SchenkE Wenzel
Mar 5, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Craig M Walker
Mar 5, 2010·Journal of Endovascular Therapy : an Official Journal of the International Society of Endovascular Specialists·Nicolas W ShammasAndrew N Shammas
Feb 16, 2013·Journal of Thrombosis and Haemostasis : JTH·F MullierJ-M Dogné
Nov 8, 2001·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·E Lindhoff-LastR Bauersachs
Aug 16, 2014·American Journal of Clinical Pathology·Nicole J Nelles, Wayne L Chandler
Jun 7, 2013·Artificial Organs·Qijin LuRichard A Malinauskas
Feb 5, 2021·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Harry N Magnani
Mar 12, 2003·Hematology/oncology Clinics of North America·Eugene P Frenkel, Eberhard F Mammen

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